Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9463495 | 0.86 | AGBL2 (0.34) | AGBL2F2RL1MC4RHTR2ASLC6A4 | |
| SCHEMBL13863848 | 0.84 | AGBL2 (0.38) | AGBL2F2RL1KDM4EMAPTRIPK1 | |
| SCHEMBL27830564 | 0.81 | F2RL1 (0.37) | AGBL2F2RL1HTR2AKCNH2DPP4 | |
| SCHEMBL30133776 | 0.81 | F2RL1 (0.41) | AGBL2F2RL1KDM4EMAPTRIPK1 | |
| SCHEMBL16483392 | 0.80 | KDM4E (0.40) | F2RL1KDM4EMAPTRIPK1MC4R | |
| SCHEMBL27692709 | 0.78 | SMN1; SMN2 (0.37) | KDM4ESMN1; SMN2LMNAMAPK1HTT | |
| SCHEMBL25482219 | 0.78 | DAO (0.41) | AGBL2F2RL1KDM4EMAPTDPP4 | |
| SCHEMBL27011333 | 0.77 | F2RL1 (0.33) | AGBL2F2RL1KDM4EMAPTRIPK1 | |
| SCHEMBL29453752 | 0.75 | CES2 (0.43) | MC4RSLC6A4PSEN1PSEN2APH1B | |
| SCHEMBL14774740 | 0.75 | CES2 (0.43) | MC4RSLC6A4PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101460476-B | Organic compounds | NOVARTIS AG | 2013-12-04 | — | — | CN | disclosed |
| CN-101460476-A | Organic compounds | NOVARTIS AG (CH) | 2009-06-17 | — | — | CN | disclosed |