SCHEMBL27767390

SCHEMBL27767390

C=Cc1cc(-c2ccccc2)cc(-c2ccccc2-c2ccccc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.44
TSHR P16473 1/20 0.44
PTGS2 P35354 2/20 0.37
BACE1 P56817 1/20 0.37
HSD17B10 Q99714 2/20 0.35
MAPK1 P28482 2/20 0.35
HPGD P15428 1/20 0.35
BCL2L1 Q07817 1/20 0.35
CYP2A6 P11509 1/20 0.35
ABL1 P00519 2/20 0.35
ABCB1 P08183 2/20 0.35
BCR P11274 2/20 0.35
NPC1 O15118 2/20 0.35
HTT P42858 2/20 0.35
RAB9A P51151 2/20 0.35
NPSR1 Q6W5P4 2/20 0.35
KDM4E B2RXH2 1/20 0.35
NTSR1 P30989 1/20 0.35
UHRF1 Q96T88 1/20 0.35
PTPN1 P18031 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1056804 0.89 ALDH1A1 (0.55) ALDH1A1TSHRPTGS2BACE1HSD17B10
SCHEMBL30992115 0.82 ALDH1A1 (0.53) ALDH1A1PTGS2BACE1HSD17B10MAPK1
SCHEMBL5878687 0.82 ALDH1A1 (0.52) ALDH1A1TSHRPTGS2BACE1HSD17B10
SCHEMBL28928500 0.81 ALDH1A1 (0.56) ALDH1A1TSHRPTGS2HSD17B10MAPK1
Styrene SCHEMBL11560726 0.81 ALDH1A1 (0.70) ALDH1A1TSHRPTGS2BACE1HSD17B10
SCHEMBL17183703 0.80 ALDH1A1 (0.60) ALDH1A1TSHRPTGS2BACE1HSD17B10
SCHEMBL29266808 0.80 ALDH1A1 (0.56) ALDH1A1BACE1HSD17B10MAPK1HPGD
SCHEMBL368887 0.79 ALDH1A1 (0.59) ALDH1A1TSHRPTGS2HSD17B10MAPK1
SCHEMBL8759106 0.79 ALDH1A1 (0.59) ALDH1A1TSHRPTGS2BACE1HSD17B10
SCHEMBL8757855 0.77 ALDH1A1 (0.56) ALDH1A1TSHRPTGS2BCL2L1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101463042-B Silicon-containing benzocyclobutene resin, intermediate thereof and preparation of the resin and intermediate CHINESE ACAD INST CHEMISTRY 2012-01-11 CN disclosed
CN-101463042-A Silicon-containing benzocyclobutene resin, intermediate thereof and preparation of the resin and intermediate CHINESE ACAD INST CHEMISTRY (CN) 2009-06-24 CN disclosed