Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.43 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.43 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL6059851 | 0.95 | PTGS2 (0.39) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| SCHEMBL376906 | 0.90 | PTGS2 (0.51) | ALOX5PTGS2PPARAPPARGLTB4R | |
| SCHEMBL14352393 | 0.90 | PTGS2 (0.51) | ALOX5PTGS2PPARAPPARGLTB4R | |
| SCHEMBL29728686 | 0.90 | PTGS2 (0.51) | ALOX5PTGS2PPARAPPARGLTB4R | |
| SCHEMBL271593 | 0.90 | PTGS2 (0.51) | ALOX5PTGS2PPARAPPARGLTB4R | |
| SCHEMBL465412 | 0.90 | PTGS2 (0.51) | ALOX5PTGS2PPARAPPARGLTB4R | |
| SCHEMBL9339452 | 0.90 | PTGS2 (0.51) | ALOX5PTGS2PPARAPPARGLTB4R | |
| SCHEMBL11127206 | 0.90 | PTGS2 (0.51) | ALOX5PTGS2PPARAPPARGLTB4R | |
| SCHEMBL30992106 | 0.90 | PTGS2 (0.51) | ALOX5PTGS2PPARAPPARGLTB4R | |
| SCHEMBL29156211 | 0.90 | PTGS2 (0.51) | ALOX5PTGS2PPARAPPARGLTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 167 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250270427-A1 | ADHESIVE COMPOSITION AND USE THEREOF | TOAGOSEI CO., LTD. (JP) | 2025-08-28 | — | — | US | disclosed |
| CN-118804947-B | Ionomer resin composition | 可乐丽美国股份有限公司 | 2025-05-23 | — | — | CN | disclosed |
| CN-120035613-A | Acetals of ethylene vinyl alcohol copolymers, compositions and barrier materials comprising the acetals | 株式会社可乐丽 | 2025-05-23 | — | — | CN | disclosed |
| CN-119654372-A | Method for recycling post-consumer and/or post-industry use impact modified polymers | 盛禧奥欧洲有限责任公司 | 2025-03-18 | — | — | CN | disclosed |
| US-20250058554-A1 | IONOMER INTERLAYER WITH ENHANCED ADHESION PROPERTIES | KURARAY AMERICA, INC. (US) | 2025-02-20 | — | — | US | disclosed |
| CN-119487597-A | Electrolytic capacitor, method for manufacturing the same, and holder | 爱尔那株式会社 | 2025-02-18 | — | — | CN | disclosed |
| CN-119371707-A | Method for producing polyamide resin foam particles and method for producing polyamide resin foam molded body | 株式会社JSP | 2025-01-28 | — | — | CN | disclosed |
| CN-119317879-A | Diluent composition and method for manufacturing semiconductor device using the same | 三菱瓦斯化学株式会社 | 2025-01-14 | — | — | CN | disclosed |
| CN-119301211-A | Adhesive composition and article | ＡＧＣ株式会社 | 2025-01-10 | — | — | CN | disclosed |
| CN-119213093-A | Adhesive composition and adhesive sheet | 爱天思株式会社 | 2024-12-27 | — | — | CN | disclosed |
| CN-102522579-A | Fuel supplies for fuel cells | BIC SOC | 2012-06-27 | — | — | CN | disclosed |
| CN-101233180-B | Fuel supply device for fuel cell | BIC SOC | 2012-03-07 | — | — | CN | disclosed |
| US-20100173146-A1 | LAMINATE AND PRODUCTION METHOD THEREOF | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-07-08 | — | — | US | disclosed |
| CN-101233180-A | Fuel supply device for fuel cell | BIC SOC (FR) | 2008-07-30 | — | — | CN | disclosed |
| WO-2002059221-A2 | ANTIFOULING AGENT COMPRISING A N-PHENYL-N'-2,6-DIFLUOROBENZOYL UREA DERIVATIVE | SDS BIOTECH K.K. (JP) | 2002-08-01 | — | — | WO | disclosed |
| EP-1006134-A1 | NORBORNENE POLYMER AND PROCESS FOR THE PREPARATION THEREOF | NIPPON ZEON CO., LTD. (JP) | 2000-06-07 | — | — | EP | disclosed |
| EP-0791630-B1 | Thermoplastic resin composition improved in terms of prevention of mold contamination | JAPAN POLYCHEM CORP (JP) | 1999-06-30 | — | — | EP | disclosed |
| US-5889099-A | CONTAINING A STERIC HINDERED AMINE | JAPAN POLYCHEM CORPORATION (JP) | 1999-03-30 | — | — | US | disclosed |
| EP-0791630-A1 | Thermoplastic resin composition improved in terms of prevention of mold contamination | Japan Polychem Corporation (JP) | 1997-08-27 | — | — | EP | disclosed |
| US-5356981-A | An inorganic copper compound adsorbed into hydrotalcite; polyvinyl chloride | ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) | 1994-10-18 | — | — | US | disclosed |