Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GPR4 | P46093 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28784755 | 1.00 | ACVR1 (0.33) | ACVR1KDM4ERAD52L3MBTL1GPR4 | |
| SCHEMBL28823410 | 0.91 | GPR4 (0.37) | L3MBTL1GPR4GRIN2BCTSK | |
| SCHEMBL27919676 | 0.91 | GPR4 (0.37) | L3MBTL1GPR4GRIN2BCTSK | |
| SCHEMBL27789441 | 0.91 | MAPT (0.37) | KDM4EMAPT | |
| SCHEMBL27901899 | 0.90 | GPR4 (0.39) | L3MBTL1GPR4GRIN2BCTSK | |
| SCHEMBL22189937 | 0.90 | GPR4 (0.39) | L3MBTL1GPR4GRIN2BCTSK | |
| SCHEMBL467811 | 0.83 | GRIN2B (0.33) | KDM4EGRIN2B | |
| SCHEMBL467810 | 0.83 | GRIN2B (0.33) | KDM4EGRIN2B | |
| SCHEMBL27901893 | 0.82 | LTA4H (0.34) | KDM4EGRIN2B | |
| SCHEMBL28039255 | 0.81 | APP (0.34) | KDM4EMAPTGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101622248-B | N3-heteroaryl substituted triazoles and n5-heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2013-04-17 | — | — | CN | claimed |
| CN-101622248-A | N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2010-01-06 | — | — | CN | claimed |
| CN-101622248-B | N3-heteroaryl substituted triazoles and n5-heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2013-04-17 | — | — | CN | disclosed |
| CN-101622248-A | N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as AXL inhibitors | RIGEL PHARMACEUTICALS INC | 2010-01-06 | — | — | CN | disclosed |