Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728136 | 0.80 | KDM4E (0.50) | KMT2ATP53ALOX15MAPK1KDM4E | |
| SCHEMBL27849214 | 0.79 | ELANE (0.45) | BCAT2KMT2ATP53ALOX15MAPK1 | |
| SCHEMBL27767996 | 0.75 | MAPK1 (0.40) | KMT2ATP53ALOX15MAPK1KDM4E | |
| SCHEMBL6623848 | 0.74 | BCAT2 (0.55) | BCAT2KMT2ATP53ALOX15MAPK1 | |
| SCHEMBL8778284 | 0.72 | KEAP1 (0.42) | KMT2ATP53ALOX15MAPK1PTGS2 | |
| SCHEMBL10258518 | 0.71 | TP53 (0.38) | BCAT2KMT2ATP53ALOX15MAPK1 | |
| SCHEMBL274364 | 0.71 | FABP3 (0.53) | BCAT2TP53MAPK1KDM4ELMNA | |
| SCHEMBL28889801 | 0.71 | PLA2G10 (0.37) | KMT2AMAPK1MEN1ALOX5LMNA | |
| SCHEMBL27768002 | 0.71 | KMT2A (0.36) | BCAT2KMT2AMAPK1MEN1ALDH1A1 | |
| SCHEMBL27789564 | 0.70 | KDM4E (0.54) | BCAT2KMT2AKDM4EMEN1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101605784-B | Aza-bridged-ring compound | ASTELLAS PHARMA INC JP | 2013-04-10 | — | — | CN | disclosed |
| CN-101605784-A | Aza-bridged-ring compound | ASTELLAS PHARMA INC (JP) | 2009-12-16 | — | — | CN | disclosed |