Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27768109 | 0.80 | BCAT2 (0.45) | KDM4EHPGDHSD17B10KMT2ATP53 | |
| SCHEMBL27849214 | 0.79 | ELANE (0.45) | KDM4EHPGDHSD17B10KMT2ATP53 | |
| SCHEMBL27767996 | 0.79 | MAPK1 (0.40) | KDM4EHPGDKMT2ATP53ALOX15 | |
| SCHEMBL8778284 | 0.77 | KEAP1 (0.42) | HPGDKMT2ATP53ALOX15MAPK1 | |
| SCHEMBL3321379 | 0.75 | KDM4E (0.56) | KDM4EHPGDHSD17B10KMT2ATP53 | |
| SCHEMBL765304 | 0.74 | KDM4E (0.44) | KDM4EHPGDHSD17B10KMT2AALDH1A1 | |
| SCHEMBL1834873 | 0.73 | KDM4E (0.61) | KDM4EHPGDHSD17B10KMT2AALOX15 | |
| SCHEMBL5728055 | 0.73 | KDM4E (0.43) | KDM4EHPGDHSD17B10KMT2AMAPK1 | |
| SCHEMBL11925422 | 0.72 | KDM4E (0.70) | KDM4EHPGDHSD17B10KMT2AALDH1A1 | |
| SCHEMBL2186248 | 0.72 | KDM4E (0.44) | KDM4EHPGDHSD17B10KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1694665-A2 | SUBSTITUTED THIOPHENES | AiCuris GmbH & Co. KG (DE) | 2006-08-30 | — | — | EP | disclosed |
| WO-2005063734-A2 | SUBSTITUTED THIOPHENES | AICURIS GMBH & CO. KG (DE) | 2005-07-14 | — | — | WO | disclosed |