Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375843 | 0.85 | KDM4E (0.59) | ABCB1KDM4EMEN1USP2TSHR | |
| SCHEMBL22656552 | 0.84 | POLB (0.50) | KDM4EMEN1USP2TSHRKMT2A | |
| SCHEMBL6571686 | 0.84 | MAPT (0.52) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL12466303 | 0.83 | ALDH1A1 (0.54) | ABCB1KDM4EMEN1TSHRKMT2A | |
| SCHEMBL3618678 | 0.83 | ALDH1A1 (0.56) | ABCB1KDM4EMEN1USP2TSHR | |
| SCHEMBL20235270 | 0.82 | ALDH1A1 (0.52) | MEN1TSHRKMT2AALDH1A1MAPT | |
| SCHEMBL31425872 | 0.82 | ALDH1A1 (0.52) | MEN1TSHRKMT2AALDH1A1MAPT | |
| SCHEMBL18702668 | 0.82 | ABCB1 (0.71) | ABCB1USP2TSHRALDH1A1RAB9A | |
| SCHEMBL7823764 | 0.80 | L3MBTL1 (0.64) | ABCB1KDM4EMEN1USP2TSHR | |
| SCHEMBL7862085 | 0.78 | NOTUM (0.53) | MEN1TSHRKMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161266-A1 | Benzofuran derivatives as orexin receptor antagonists | EVOTEC Neurosciences GmbH (DE) | 2010-03-10 | — | — | EP | disclosed |
| EP-2161266-A1 | Benzofuran derivatives as orexin receptor antagonists | EVOTEC Neurosciences GmbH (DE) | 2010-03-10 | — | — | EP | disclosed |