Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27734707 | 0.88 | TGFBR1 (0.42) | GPR119TGFBR1KDM4EPKMPIK3CA | |
| SCHEMBL27755079 | 0.87 | GPR119 (0.46) | GPR119TGFBR1 | |
| SCHEMBL27769026 | 0.85 | PIK3CA (0.44) | PIK3CDGPR119TGFBR1KDM4EPKM | |
| SCHEMBL27755184 | 0.84 | GPR119 (0.58) | GPR119TGFBR1 | |
| SCHEMBL27734735 | 0.83 | KDM4E (0.42) | GPR119TGFBR1KDM4EPKMSYK | |
| SCHEMBL388397 | 0.83 | GPR119 (0.46) | PIK3CDGPR119TGFBR1TBK1PIK3CA | |
| SCHEMBL1067975 | 0.83 | TGFBR1 (0.42) | GPR119TGFBR1KDM4EPKMALDH1A1 | |
| SCHEMBL391248 | 0.82 | GPR119 (0.53) | PIK3CDGPR119TBK1ALDH1A1 | |
| SCHEMBL27755009 | 0.81 | GPR119 (0.47) | GPR119KDM4EPKMPIK3CAPRKDC | |
| SCHEMBL27734896 | 0.80 | KDM4E (0.48) | GPR119TGFBR1KDM4EPKMHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101420941-A | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, and related combination therapies | ARENA PHARM INC (US) | 2009-04-29 | — | — | CN | disclosed |