Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 12/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27734735 | 0.89 | KDM4E (0.42) | TGFBR1KDM4EPKMGPR119SYK | |
| SCHEMBL27755184 | 0.85 | GPR119 (0.58) | TGFBR1GPR119 | |
| SCHEMBL391745 | 0.83 | TBK1 (0.45) | TGFBR1GPR119NPC1ALDH1A1MAPT | |
| SCHEMBL27769006 | 0.83 | PIK3CD (0.45) | TGFBR1KDM4EPKMGPR119ALDH1A1 | |
| SCHEMBL27734707 | 0.82 | TGFBR1 (0.42) | TGFBR1KDM4EPKMGPR119MAPT | |
| SCHEMBL390829 | 0.81 | GPR119 (0.48) | GPR119NPC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL27755079 | 0.81 | GPR119 (0.46) | TGFBR1GPR119 | |
| SCHEMBL27734896 | 0.79 | KDM4E (0.48) | TGFBR1KDM4EPKMGPR119MAPT | |
| SCHEMBL27755009 | 0.78 | GPR119 (0.47) | KDM4EPKMGPR119 | |
| SCHEMBL27755016 | 0.78 | GPR119 (0.45) | TGFBR1KDM4EPKMGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-B1 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | ARENA PHARM INC (US) | 2011-01-12 | — | — | EP | disclosed |
| CN-101420941-A | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, and related combination therapies | ARENA PHARM INC (US) | 2009-04-29 | — | — | CN | disclosed |
| CN-101332303-A | Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level | ARENA PHARM INC (US) | 2008-12-31 | — | — | CN | disclosed |