Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 8/20 | 0.59 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 3/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6805238 | 0.84 | KDM4E (0.67) | ESRRGMAPTESR1ESR2HSD17B1 | |
| SCHEMBL3749139 | 0.84 | HPGDS (0.69) | ESRRGTP53MAPTESR1ESR2 | |
| SCHEMBL71536 | 0.84 | RAB9A (0.66) | TP53MAPTHSD17B1HSD17B2HDAC6 | |
| SCHEMBL13525288 | 0.84 | HSD17B1 (0.59) | ESRRGTP53MAPTESR1ESR2 | |
| SCHEMBL3918681 | 0.82 | HPGDS (0.59) | ESRRGTP53MAPTESR1ESR2 | |
| SCHEMBL6477476 | 0.82 | KDM4E (0.58) | ESRRGTP53MAPTHSD17B1HSD17B2 | |
| SCHEMBL2491378 | 0.81 | RAB9A (0.72) | ESRRGTP53MAPTHSD17B1HSD17B2 | |
| SCHEMBL27565420 | 0.80 | ESRRG (0.59) | ESRRGTP53MAPTRPS6KB1CSNK1D | |
| SCHEMBL13524643 | 0.80 | HPGDS (0.48) | TP53GSK3AGSK3BAURKBHSD17B1 | |
| SCHEMBL17208107 | 0.80 | HSD17B1 (0.56) | ESRRGMAPTRPS6KB1CSNK1DGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100584840-C | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB | 2010-01-27 | — | — | CN | disclosed |