Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433603 | 0.92 | TSHR (0.52) | PNPTSHRMAPTTP53GAA | |
| SCHEMBL3425179 | 0.85 | PNP (0.48) | PNPTSHRLMNACYP1A2CDK1 | |
| SCHEMBL7765338 | 0.84 | PNP (0.46) | PNPCYP1A2CYP3A4CYP2C19PDE5A | |
| SCHEMBL5798037 | 0.82 | GRIA1 (0.45) | PNPPDE5AGRIA1GRIA2GRIA3 | |
| SCHEMBL1533594 | 0.82 | PNP (0.44) | PNPMAPK1LMNACYP1A2CYP3A4 | |
| SCHEMBL30080348 | 0.81 | PDE5A (0.43) | PNPTSHRMAPTTP53GAA | |
| SCHEMBL30248422 | 0.79 | CYP1A2 (0.47) | PNPMAPK1LMNACYP1A2CYP3A4 | |
| SCHEMBL1286929 | 0.75 | PNP (0.50) | PNPPDE5AGRIA1GRIA2GRIA3 | |
| Guanine SCHEMBL1394087 | 0.73 | PNP (0.68) | PNPTSHRLMNACYP1A2CDK1 | |
| SCHEMBL10629409 | 0.72 | PNP (0.62) | PNPGRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1861078-A | Human AGT protein micromolecular inhibitor | UNIV HUADONG (CN) | 2006-11-15 | — | — | CN | claimed |
| CN-107235981-B | Hypoxemia activates O6- benzyl -2- nitro purine derivative and preparation method and application | 北京工业大学 | 2019-10-25 | — | — | CN | disclosed |
| CN-107235981-A | The nitro purine derivative of hypoxemia activation O6 benzyls 2 and preparation method and application | 北京工业大学 | 2017-10-10 | — | — | CN | disclosed |
| US-7825096-B2 | O6-alkylguanine-DNA alkyltransferase inactivators and beta-glucuronidase cleavable prodrugs | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-11-02 | — | — | US | disclosed |
| US-7799524-B2 | Substrates for O6-alkylguanina-DNA alkyltransferase | Ecole Polytechnique Ferdeale de Lausanne (CH) | 2010-09-21 | — | — | US | disclosed |
| EP-2134715-A2 | O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE INACTIVATORS | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008109735-A2 | O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE INACTIVATORS | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-09-12 | — | — | WO | disclosed |
| US-20070213279-A1 | O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE INACTIVATORS AND BETA-GLUCURONIDASE CLEAVABLE PRODRUGS | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE | 2007-09-13 | — | — | US | disclosed |
| CN-1861078-A | Human AGT protein micromolecular inhibitor | UNIV HUADONG (CN) | 2006-11-15 | — | — | CN | disclosed |
| WO-2006021553-A1 | METHOD FOR PROTEIN PURIFICATION AND LABELING BASED ON A CHEMOSELECTIVE REACTION | COVALYS BIOSCIENCES AG (CH) | 2006-03-02 | — | — | WO | disclosed |
| US-20060024775-A1 | Substrates for o6-alkylguanina-dna alkyltransferase | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL). (CH) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060024775-A1 | Substrates for o6-alkylguanina-dna alkyltransferase | AGT, OGG1, NUDT1 | PNP 176/4885TSHR 2155/4885MAPT 4311/4885 |
| US-20070213279-A1 | O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE INACTIVATORS AND BETA-GLUCURONIDASE CLEAVABLE PRODRUGS | UNG, OGG1, MPG | PNP 20/4885TSHR 2852/4885MAPT 4089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.