Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | FABP3 | P05413 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27925737 | 0.91 | NPC1 (0.39) | NPC1HSD11B1KCNN4FABP3FABP4 | |
| SCHEMBL27769320 | 0.89 | KCNN4 (0.38) | NPC1HSD11B1KCNN4DHODHFABP3 | |
| SCHEMBL27769411 | 0.89 | KCNN4 (0.41) | NPC1HSD11B1KCNN4PDCD1CD274 | |
| SCHEMBL27769319 | 0.86 | ALDH1A1 (0.42) | TP53ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL27748148 | 0.86 | KCNN4 (0.37) | NPC1HSD11B1KCNN4PDCD1CD274 | |
| SCHEMBL27748171 | 0.78 | TRPV1 (0.36) | HSD11B1KCNN4TP53ALDH1A1LMNA | |
| SCHEMBL16875748 | 0.77 | NPC1 (0.43) | NPC1HSD11B1DHODHTP53TSHR | |
| SCHEMBL27769340 | 0.76 | KCNN4 (0.37) | NPC1KCNN4DHODHTSHRALDH1A1 | |
| SCHEMBL27748143 | 0.76 | AKR1C2 (0.40) | NPC1HSD11B1TP53ALDH1A1MEN1 | |
| SCHEMBL27769338 | 0.75 | ALDH1A1 (0.39) | KCNN4DHODHTSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101479250-B | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-05-22 | — | — | CN | disclosed |
| CN-101479250-A | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |