Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27748142 | 0.92 | KCNN4 (0.36) | KCNN4TSHRALDH1A1LMNAHSD17B10 | |
| SCHEMBL27925722 | 0.91 | DHODH (0.39) | KCNN4TSHRALDH1A1LMNADHODH | |
| SCHEMBL27769338 | 0.87 | ALDH1A1 (0.39) | KCNN4TSHRALDH1A1LMNADHODH | |
| SCHEMBL27769320 | 0.85 | KCNN4 (0.38) | KCNN4ALDH1A1DHODHNPC1MDM2 | |
| SCHEMBL27769329 | 0.84 | ALDH1A1 (0.36) | KCNN4TSHRALDH1A1LMNAHSD17B10 | |
| SCHEMBL27748171 | 0.83 | TRPV1 (0.36) | KCNN4ALDH1A1LMNA | |
| SCHEMBL27748146 | 0.82 | FABP4 (0.36) | KCNN4TSHRALDH1A1LMNAMDM2 | |
| SCHEMBL27907613 | 0.78 | CNR2 (0.44) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL27748148 | 0.78 | KCNN4 (0.37) | KCNN4ALDH1A1DHODHNPC1 | |
| SCHEMBL27925737 | 0.76 | NPC1 (0.39) | KCNN4TSHRALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101479250-B | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-05-22 | — | — | CN | disclosed |
| CN-101479250-A | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |