Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | FABP3 | P05413 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27748148 | 0.93 | KCNN4 (0.37) | KCNN4NPC1HSD11B1CDK1CDK2 | |
| SCHEMBL27925737 | 0.91 | NPC1 (0.39) | KCNN4NPC1HSD11B1TP53FABP3 | |
| SCHEMBL27769345 | 0.89 | NPC1 (0.40) | KCNN4NPC1HSD11B1DHODHTP53 | |
| SCHEMBL27748171 | 0.89 | TRPV1 (0.36) | KCNN4HSD11B1CDK1CDK2GSK3B | |
| SCHEMBL27769411 | 0.87 | KCNN4 (0.41) | KCNN4NPC1HSD11B1DHODHTP53 | |
| SCHEMBL27769340 | 0.85 | KCNN4 (0.37) | KCNN4NPC1DHODHALDH1A1MDM2 | |
| SCHEMBL27769329 | 0.81 | ALDH1A1 (0.36) | KCNN4ALDH1A1MAPK1 | |
| SCHEMBL27748146 | 0.80 | FABP4 (0.36) | KCNN4TP53FABP4FABP5ALDH1A1 | |
| SCHEMBL16875757 | 0.78 | ALDH1A1 (0.38) | KCNN4NPC1HSD11B1DHODHALDH1A1 | |
| SCHEMBL27748142 | 0.78 | KCNN4 (0.36) | KCNN4DHODHALDH1A1MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101479250-B | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE | 2013-05-22 | — | — | CN | disclosed |
| CN-101479250-A | Tetrazole-substituted arylamides | HOFFMANN LA ROCHE (CH) | 2009-07-08 | — | — | CN | disclosed |