Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 18/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.43 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4942376 | 0.88 | DGAT1 (0.53) | DGAT1RAB9A | |
| SCHEMBL180686 | 0.88 | DGAT1 (0.50) | DGAT1RAB9A | |
| SCHEMBL4933344 | 0.88 | DGAT1 (0.50) | DGAT1RAB9AFAAHCHRM2SOAT1 | |
| SCHEMBL4939307 | 0.87 | DGAT1 (0.50) | DGAT1SOAT1 | |
| SCHEMBL27769401 | 0.83 | RAB9A (0.44) | RAB9A | |
| SCHEMBL27769670 | 0.83 | RAB9A (0.46) | RAB9A | |
| SCHEMBL4939205 | 0.80 | ALOX5 (0.56) | DGAT1RAB9ASOAT1 | |
| SCHEMBL4494798 | 0.79 | ALOX5 (0.57) | DGAT1SOAT1 | |
| SCHEMBL180791 | 0.79 | CYP1A1 (0.54) | DGAT1RAB9A | |
| SCHEMBL4939728 | 0.79 | DGAT1 (0.56) | DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101636155-A | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LAB | 2010-01-27 | — | — | CN | claimed |
| CN-101636155-A | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LAB | 2010-01-27 | — | — | CN | disclosed |