Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.39 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 8/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28095366 | 0.98 | TSHR (0.40) | MAPTSMN1; SMN2GALR3BLMLMNA | |
| Hydrochloric Acid SCHEMBL28083048 | 0.89 | MAPT (0.37) | MAPTSMN1; SMN2GALR3BLMLMNA | |
| Hydrochloric Acid SCHEMBL1238012 | 0.80 | MAPT (0.60) | MAPTSMN1; SMN2GALR3BLMLMNA | |
| SCHEMBL2424095 | 0.78 | TSHR (0.44) | SMN1; SMN2TSHRHPGDALDH1A1TP53 | |
| SCHEMBL2946080 | 0.78 | TSHR (0.59) | MAPTSMN1; SMN2GALR3BLMLMNA | |
| SCHEMBL3657429 | 0.78 | TSHR (0.44) | SMN1; SMN2TSHRHPGDALDH1A1TP53 | |
| SCHEMBL28321811 | 0.77 | TSHR (0.44) | TSHRHPGDALDH1A1TP53HIF1A | |
| Hydrochloric Acid SCHEMBL27882963 | 0.77 | MAPT (0.39) | MAPTSMN1; SMN2GALR3BLMLMNA | |
| SCHEMBL12492096 | 0.77 | TSHR (0.47) | TSHRHPGDALDH1A1TP53HIF1A | |
| Bromide SCHEMBL28073958 | 0.77 | TSHR (0.57) | MAPTSMN1; SMN2GALR3BLMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109971439-A | A kind of drilling fluid graft modified starch anti-sloughing agent and preparation method thereof | 中国石油化工股份有限公司 | 2019-07-05 | — | — | CN | claimed |
| CN-109777378-A | A kind of preparation method of resistant to high temperatures, salt resistant drilling nanoemulsions copolymer fluid loss agent | 河南省新乡市第七化工有限公司 | 2019-05-21 | — | — | CN | claimed |
| CN-109485793-A | A kind of preparation method being etherified pretreatment type quaternary ammonium cation grafting starch | 安徽工程大学 | 2019-03-19 | — | — | CN | claimed |
| CN-108949122-A | A kind of heat resisting fluid loss reducing agent and preparation method thereof | 中国石油集团工程技术研究院有限公司 | 2018-12-07 | — | — | CN | claimed |
| CN-104327810-B | A kind of low frictional resistance drilling fluid of Solid Free | 中国石油化工集团公司 | 2018-08-31 | — | — | CN | claimed |
| CN-104140794-B | A kind of high temperature-resisting oil-in-water drilling fluid | 中国石油化工股份有限公司 | 2017-11-17 | — | — | CN | claimed |
| CN-106794132-A | Oral composition for alleviating dentin hypersensitivity | 日油株式会社 | 2017-05-31 | — | — | CN | claimed |
| CN-104098746-B | Adamantyl contained hydrophobic association zwitter-ion starch and preparation method thereof | 西南石油大学 | 2017-01-25 | — | — | CN | claimed |
| CN-106318348-A | Drilling fluid for resisting heavy oil pollution | 中石化石油工程技术服务有限公司 | 2017-01-11 | — | — | CN | claimed |
| CN-103509535-B | The filtrate reducing method of water-base drilling fluid and the preparation method of fluid loss additive | 中国石油化工股份有限公司 | 2016-12-21 | — | — | CN | claimed |
| CN-105295859-A | Modified starch fluid loss agent for drilling fluid | CHINA PETROLEUM & CHEMICAL | 2016-02-03 | — | — | CN | claimed |
| CN-105026638-A | Vane arrangement having alternating vanes with different trailing edge profile | ELLIOTT CO | 2015-11-04 | — | — | CN | claimed |
| CN-105017485-A | Adamantyl-containing hydrophobic association zwitter-ion xanthan gum and preparation method thereof | CHINA PETROLEUM & CHEMICAL | 2015-11-04 | — | — | CN | claimed |
| CN-104327810-A | Solid-phase-free low frictional resistance drilling fluid | CHINA PETROCHEMICAL CORP | 2015-02-04 | — | — | CN | claimed |
| CN-104312557-A | High-density low-frictional-resistance drilling fluid | CHINA PETROCHEMICAL CORP | 2015-01-28 | — | — | CN | claimed |
| CN-110507561-A | The lip composition of emulsion form and the processing method for using it | OREAL | 2019-11-29 | — | — | CN | disclosed |
| CN-106456786-B | For controllably discharging the tablet of active principle | 科德宝两合公司 | 2019-10-11 | — | — | CN | disclosed |
| CN-104272174-A | Contact lens care preparation and packaging solution | NIPPON OIL CORP | 2015-01-07 | — | — | CN | disclosed |
| CN-101429427-B | Process for preparing drilling fluid finishing agent of amphoteric ion sulphonate polymer | DRILLING ENG TECH RES INST ZHONGYUAN PETROLEUM EXPLORATION BUREAU SINOPEC | 2012-12-12 | — | — | CN | disclosed |
| CN-101429427-A | Process for preparing drilling fluid finishing agent of amphoteric ion sulphonate polymer | DRILLING ENGINEERING TECHNOLOG (CN) | 2009-05-13 | — | — | CN | disclosed |