Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.59 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4003528 | 0.84 | ABL1 (0.58) | ABL1PDGFRBPDGFRASRCSMN1; SMN2 | |
| SCHEMBL4000628 | 0.84 | ABL1 (0.69) | ABL1PDGFRBPDGFRASRCSMN1; SMN2 | |
| SCHEMBL2941787 | 0.84 | ABL1 (0.75) | ABL1PDGFRBPDGFRASRCSMN1; SMN2 | |
| SCHEMBL1762 | 0.74 | ABL1 (1.00) | ABL1PDGFRBPDGFRASRCSMN1; SMN2 | |
| SCHEMBL5465088 | 0.74 | RAB9A (0.59) | ABL1SMN1; SMN2MAPTKMT2APOLB | |
| SCHEMBL4002108 | 0.74 | ABL1 (0.71) | ABL1PDGFRBPDGFRASRCSMN1; SMN2 | |
| SCHEMBL13874759 | 0.74 | MAPT (1.00) | SMN1; SMN2MAPTKMT2APOLBL3MBTL1 | |
| SCHEMBL5465340 | 0.72 | ALDH1A1 (0.61) | ABL1PDGFRBPDGFRASRCSMN1; SMN2 | |
| SCHEMBL3523274 | 0.72 | ABL1 (0.65) | ABL1PDGFRBPDGFRASRCSMN1; SMN2 | |
| SCHEMBL4001863 | 0.71 | MAPT (0.67) | ABL1PDGFRBPDGFRASRCSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101605766-A | Pyrimidine derivatives and they are as the purposes of kinase inhibitor | CGI PHARMACEUTICALS INC (US) | 2009-12-16 | — | — | CN | claimed |
| CN-101605766-A | Pyrimidine derivatives and they are as the purposes of kinase inhibitor | CGI PHARMACEUTICALS INC (US) | 2009-12-16 | — | — | CN | disclosed |