Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | RORB | Q92753 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11386105 | 0.80 | TGFBR1 (0.44) | BACE1TRPA1ALDH1A1JAK3ALOX5AP | |
| SCHEMBL7609085 | 0.78 | ERN1 (0.38) | ERN1ALDH1A1MEN1KMT2AMAPKAPK2 | |
| SCHEMBL29935212 | 0.77 | EGFR (0.45) | ERN1ALDH1A1MEN1KMT2AMAPKAPK2 | |
| SCHEMBL2084619 | 0.77 | EGFR (0.45) | ERN1ALDH1A1MEN1KMT2AMAPKAPK2 | |
| SCHEMBL28778071 | 0.75 | MAP4K4 (0.49) | NFE2L2 | |
| SCHEMBL2615986 | 0.74 | CYP2A6 (0.47) | CYP2A6TNKS2ABL1BACE1TRPA1 | |
| SCHEMBL27751607 | 0.74 | MAP4K4 (0.46) | ERN1NFE2L2ALDH1A1KMT2AJAK2 | |
| SCHEMBL3362961 | 0.74 | PIK3C3 (0.61) | CYP2A6PIK3C3ABL1BACE1TRPA1 | |
| SCHEMBL1094682 | 0.73 | ERN1 (0.45) | ERN1ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL25120516 | 0.72 | ALDH1A1 (0.45) | CYP2A6NFE2L2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101506149-A | Prolyl hydroxylase inhibitors and methods of use | PROCTER & GAMBLE (US) | 2009-08-12 | — | — | CN | claimed |
| CN-101506149-B | Prolyl hydroxylase inhibitors and methods of use | PROCTER & GAMBLE | 2012-11-14 | — | — | CN | disclosed |
| CN-101506149-A | Prolyl hydroxylase inhibitors and methods of use | PROCTER & GAMBLE (US) | 2009-08-12 | — | — | CN | disclosed |