Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2779027 | 0.83 | MEN1 (0.43) | MEN1KMT2AALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL15261415 | 0.83 | HPGD (0.57) | HTTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL12802344 | 0.83 | L3MBTL1 (0.58) | HTTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL4938661 | 0.81 | KDM4E (0.56) | HTTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL4862640 | 0.81 | LMNA (0.47) | HTTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL5913849 | 0.81 | CYP3A4 (0.59) | HTTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL5034363 | 0.80 | L3MBTL1 (0.48) | HTTTSHRMEN1KMT2AEPHX2 | |
| SCHEMBL2780716 | 0.79 | HPGD (0.39) | HTTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL25342779 | 0.79 | LMNA (0.46) | HTTTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL3242672 | 0.78 | RAB9A (0.45) | TSHRMEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103429-A1 | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists | PFIZER INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010103429-A1 | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists | PFIZER INC. (US) | 2010-09-16 | — | — | WO | disclosed |