Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 7/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 3/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778013 | 0.87 | PNMT (0.39) | PNMTADRA2AADRA2BADRA2CAR | |
| SCHEMBL2780995 | 0.83 | MTNR1A (0.40) | PNMTADRA2AADRA2BADRA2CAR | |
| SCHEMBL2779601 | 0.78 | MTNR1A (0.39) | PNMTADRA2AADRA2BADRA2CAR | |
| SCHEMBL6192806 | 0.75 | PNMT (0.37) | PNMTADRA2AADRA2BADRA2CMTNR1A | |
| SCHEMBL6192228 | 0.75 | PNMT (0.50) | PNMTADRA2AADRA2BADRA2CMTNR1A | |
| SCHEMBL2777817 | 0.75 | CYP1A2 (0.41) | PNMTADRA2AADRA2BADRA2CAR | |
| SCHEMBL2780428 | 0.74 | MTNR1A (0.34) | PNMTADRA2AADRA2BADRA2CMTNR1A | |
| SCHEMBL19510662 | 0.74 | KMT2A (0.45) | MTNR1ARIPK1FFAR4 | |
| SCHEMBL30350726 | 0.74 | KMT2A (0.45) | MTNR1ARIPK1FFAR4 | |
| SCHEMBL2775802 | 0.73 | AAK1 (0.37) | PNMTARMTNR1ARIPK1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139886-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116308-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-10-02 | — | — | WO | disclosed |