Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777645 | 0.81 | MTNR1A (0.35) | MTNR1ARIPK1MEN1KMT2APOLB | |
| SCHEMBL30358050 | 0.76 | IGF1R (0.46) | MTNR1ARIPK1MEN1KMT2APOLB | |
| SCHEMBL3893061 | 0.76 | IGF1R (0.46) | MTNR1ARIPK1MEN1KMT2APOLB | |
| SCHEMBL2777471 | 0.74 | PNMT (0.38) | MTNR1ARIPK1ADRA2APNMTADRA2B | |
| SCHEMBL12878960 | 0.72 | L3MBTL1 (0.38) | MEN1KMT2APOLBADRA2APNMT | |
| SCHEMBL2780995 | 0.71 | MTNR1A (0.40) | MTNR1ARIPK1ADRA2APNMTADRA2B | |
| SCHEMBL12450088 | 0.69 | KMT2A (0.42) | MTNR1AMEN1KMT2APOLBLMNA | |
| SCHEMBL6192228 | 0.68 | PNMT (0.50) | MTNR1APOLBADRA2APNMTADRA2B | |
| SCHEMBL8652335 | 0.68 | MTNR1A (0.41) | MTNR1ARIPK1MEN1KMT2APOLB | |
| SCHEMBL16585592 | 0.68 | PNMT (0.45) | RIPK1POLBADRA2APNMTADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139886-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | Neuraxon Inc. (CA) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008116308-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-10-02 | — | — | WO | disclosed |