Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.39 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5117884 | 0.84 | KEAP1 (0.41) | HRH3KDM4EALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL2777464 | 0.77 | FGFR1 (0.40) | HRH3KDM4EALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL14078757 | 0.73 | CHRNB2 (0.46) | KDM4EALDH1A1CHRNB2CHRNA4SMN1; SMN2 | |
| SCHEMBL5112395 | 0.72 | ADORA2A (0.43) | HRH3KDM4EALDH1A1CHRNB2CHRNA4 | |
| SCHEMBL2777987 | 0.72 | POLB (0.41) | KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL2776095 | 0.72 | CA12 (0.34) | KDM4EALDH1A1MAPT | |
| SCHEMBL14428434 | 0.70 | — | — | |
| SCHEMBL5461338 | 0.68 | CA12 (0.40) | KDM4ESMN1; SMN2 | |
| SCHEMBL14078753 | 0.67 | TAAR1 (0.35) | LTA4HFGFR1 | |
| SCHEMBL8430078 | 0.66 | HRH3 (0.72) | HRH3KDM4EALDH1A1LTA4HKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197534-A1 | Novel 1,2,4-benzotriazine-1,4-dioxides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-08-23 | — | — | US | claimed |
| EP-1723125-A1 | NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES | Auckland Uniservices Limited (NZ) | 2006-11-22 | — | — | EP | claimed |
| WO-2005082867-A1 | NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-09-09 | — | — | WO | claimed |
| US-7816521-B2 | 1,2,4-benzotriazine-1,4-dioxides | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-10-19 | — | — | US | disclosed |
| US-7816521-B2 | 1,2,4-benzotriazine-1,4-dioxides | AUCKLAND UNISERVICES LIMITED (NZ) | 2010-10-19 | — | — | US | disclosed |
| US-20070197534-A1 | Novel 1,2,4-benzotriazine-1,4-dioxides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-08-23 | — | — | US | disclosed |
| US-20070197534-A1 | Novel 1,2,4-benzotriazine-1,4-dioxides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-08-23 | — | — | US | disclosed |
| EP-1723125-A1 | NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES | Auckland Uniservices Limited (NZ) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005082867-A1 | NOVEL 1,2,4-BENZOTRIAZINE-1,4-DIOXIDES | AUCKLAND UNISERVICES LIMITED (NZ) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197534-A1 | Novel 1,2,4-benzotriazine-1,4-dioxides | HIF1AN, HIF1A, HYOU1 | HRH3 786/4885KDM4E 188/4885ALDH1A1 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.