Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 6/20 | 0.51 |
| ▸ | RORC | P51449 | 9/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27776543 | 1.00 | P2RX7 (0.51) | P2RX7RORCPDE2APPARGF11 | |
| SCHEMBL27797239 | 0.91 | P2RX7 (0.42) | P2RX7RORC | |
| SCHEMBL27797240 | 0.91 | P2RX7 (0.42) | P2RX7RORC | |
| SCHEMBL27776449 | 0.83 | P2RX7 (0.51) | P2RX7RORC | |
| SCHEMBL27776447 | 0.83 | P2RX7 (0.51) | P2RX7RORC | |
| SCHEMBL27797214 | 0.81 | P2RX7 (0.46) | P2RX7F11 | |
| SCHEMBL306167 | 0.80 | P2RX7 (0.61) | P2RX7PPARG | |
| SCHEMBL306166 | 0.80 | P2RX7 (0.61) | P2RX7PPARG | |
| SCHEMBL8132956 | 0.78 | P2RX7 (0.46) | P2RX7 | |
| SCHEMBL305888 | 0.75 | P2RX7 (0.84) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101686680-A | Bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS INC | 2010-03-31 | — | — | CN | claimed |
| CN-101686680-A | Bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS INC | 2010-03-31 | — | — | CN | disclosed |