Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 9/20 | 0.42 |
| ▸ | RORC | P51449 | 4/20 | 0.35 |
| ▸ | DPP4 | P27487 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27797240 | 1.00 | P2RX7 (0.42) | P2RX7RORCDPP4SLC6A2SLC6A4 | |
| SCHEMBL27776544 | 0.91 | P2RX7 (0.51) | P2RX7RORC | |
| SCHEMBL27776543 | 0.91 | P2RX7 (0.51) | P2RX7RORC | |
| SCHEMBL4438657 | 0.85 | P2RX7 (0.46) | P2RX7DPP4 | |
| SCHEMBL27797214 | 0.85 | P2RX7 (0.46) | P2RX7DPP4 | |
| SCHEMBL8132956 | 0.82 | P2RX7 (0.46) | P2RX7 | |
| SCHEMBL27776447 | 0.79 | P2RX7 (0.51) | P2RX7RORC | |
| SCHEMBL27776449 | 0.79 | P2RX7 (0.51) | P2RX7RORC | |
| SCHEMBL307857 | 0.78 | P2RX7 (0.50) | P2RX7 | |
| SCHEMBL307031 | 0.76 | P2RX7 (0.52) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101686680-A | Bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS INC | 2010-03-31 | — | — | CN | claimed |
| CN-101686680-A | Bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS INC | 2010-03-31 | — | — | CN | disclosed |