Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP2 | P42575 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28785699 | 0.78 | TP53 (0.41) | ALDH1A1RAB9AL3MBTL1HTTMEN1 | |
| SCHEMBL1654361 | 0.76 | EGFR (0.36) | ALDH1A1ANPEPL3MBTL1ATMGAA | |
| SCHEMBL11701504 | 0.71 | KDM4E (0.42) | ALDH1A1RAB9AL3MBTL1ATMMEN1 | |
| SCHEMBL14764227 | 0.70 | L3MBTL1 (0.50) | ALDH1A1ANPEPRAB9AL3MBTL1HTT | |
| SCHEMBL18496354 | 0.70 | ALDH1A1 (0.36) | ALDH1A1L3MBTL1TP53EGFR | |
| SCHEMBL27776939 | 0.70 | KDM4E (0.39) | ALDH1A1L3MBTL1HTTMEN1KMT2A | |
| SCHEMBL27617116 | 0.68 | ALDH1A1 (0.40) | ALDH1A1ATMMEN1KMT2ALMNA | |
| SCHEMBL8644889 | 0.67 | TDP1 (0.48) | ALDH1A1RAB9AL3MBTL1HTTATM | |
| SCHEMBL27791867 | 0.67 | MAPK1 (0.47) | ALDH1A1L3MBTL1KMT2AGAALMNA | |
| SCHEMBL30205969 | 0.66 | EGFR (0.39) | ALDH1A1RAB9AL3MBTL1ATMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101678020-B | Quinoxaline derivatives as inhibitors of the tyrosine kinase activity of Janus kinases | NOVARTIS AG | 2012-08-15 | — | — | CN | disclosed |
| CN-101678020-A | Quinoxaline derivatives as inhibitors of the tyrosine kinase activity of Janus kinases | NOVARTIS AG | 2010-03-24 | — | — | CN | disclosed |