Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL28096283 | 0.92 | LMNA (0.58) | ALDH1A1MAPTKMT2APOLBLMNA | |
| SCHEMBL118930 | 0.92 | LMNA (0.58) | ALDH1A1MAPTKMT2APOLBLMNA | |
| Water SCHEMBL27554784 | 0.90 | LMNA (0.56) | ALDH1A1MAPTKMT2APOLBLMNA | |
| Ammonia Solution, Strong SCHEMBL27504543 | 0.90 | F2 (0.56) | ALDH1A1MAPTKMT2APOLBLMNA | |
| SCHEMBL27844849 | 0.90 | LMNA (0.56) | ALDH1A1MAPTKMT2APOLBLMNA | |
| SCHEMBL27391027 | 0.90 | LMNA (0.56) | ALDH1A1MAPTKMT2APOLBLMNA | |
| Bromobenzene SCHEMBL27920419 | 0.82 | MAPT (0.56) | ALDH1A1MAPTKMT2APOLBLMNA | |
| SCHEMBL27800215 | 0.81 | TSHR (0.53) | ALDH1A1MAPTKMT2APOLBLMNA | |
| Carbamic Acid SCHEMBL27556489 | 0.81 | LMNA (0.61) | ALDH1A1MAPTKMT2APOLBLMNA | |
| SCHEMBL30849215 | 0.80 | PARP10 (0.42) | ALDH1A1MAPTKMT2ALMNAF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101687818-B | Crystalline, amorphous or salt of methyl N- [3- (6, 7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl ] p-aminocarbonylbenzoic acid | EISAI R&D MAN CO LTD | 2012-08-22 | — | — | CN | disclosed |
| CN-101687818-A | Crystalline, amorphous or salt of methyl N- [ 3- (6, 7-dimethoxy-2-methylaminoquinazolin-4-yl) phenyl ] p-aminocarbonylbenzoic acid | EISAI R&D MAN CO LTD | 2010-03-31 | — | — | CN | disclosed |