Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27800771 | 0.96 | LMNA (0.36) | LMNAALDH1A1KDM4ECYP3A4RECQL | |
| Hydrochloric Acid SCHEMBL2150060 | 0.95 | LMNA (0.37) | LMNAALDH1A1KDM4ECYP3A4RECQL | |
| Bromide SCHEMBL2149556 | 0.95 | LMNA (0.37) | LMNAALDH1A1KDM4ECYP3A4RECQL | |
| SCHEMBL4189303 | 0.77 | KAT2B (0.37) | LMNAALDH1A1KDM4ETDP1KMT2A | |
| Acetic Acid SCHEMBL27821312 | 0.75 | ALDH1A1 (0.34) | LMNAALDH1A1KDM4ECYP3A4POLB | |
| Glycine SCHEMBL27820101 | 0.73 | PARP1 (0.31) | LMNA | |
| Glycine SCHEMBL27839731 | 0.71 | ALDH1A1 (0.32) | ALDH1A1KDM4EPOLB | |
| Bromide SCHEMBL2956997 | 0.70 | MAPT (0.50) | LMNAALDH1A1KDM4ECYP3A4RECQL | |
| Hydrochloric Acid SCHEMBL27820096 | 0.68 | TOP2A (0.31) | LMNAALDH1A1 | |
| Water SCHEMBL27820105 | 0.68 | ALDH1A1 (0.31) | LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101684106-B | Thiazole onium salt compound and application for treating diseases relative to protein aging thereof | BEIJING MOLYKOTE TECHNOLOGY CO LTD | 2013-06-12 | — | — | CN | claimed |
| CN-101684106-A | Thiazole onium salt compound and application for treating diseases relative to protein aging thereof | BEIJING MOLYKOTE TECHNOLOGY CO | 2010-03-31 | — | — | CN | claimed |
| CN-105377823-B | Thiazole inner salt compound, preparation method and application thereof | 中国人民解放军军事医学科学院毒物药物研究所 | 2017-12-01 | — | — | CN | disclosed |
| CN-104277011-A | Thiazolium inner salt compound and its use in treatment on protein aging-related diseases | INST PHARM & TOXICOLOGY AMMS | 2015-01-14 | — | — | CN | disclosed |