Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2150060 | 0.96 | LMNA (0.37) | LMNAALDH1A1KDM4ECYP3A4RECQL | |
| SCHEMBL4189303 | 0.79 | KAT2B (0.37) | LMNAALDH1A1KDM4ETDP1KMT2A | |
| Bromide SCHEMBL2956997 | 0.75 | MAPT (0.50) | LMNAALDH1A1KDM4ECYP3A4RECQL | |
| Hydrochloric Acid SCHEMBL5956525 | 0.63 | LMNA (0.37) | LMNAALDH1A1KDM4ECYP3A4RECQL | |
| Hydrochloric Acid SCHEMBL5956495 | 0.63 | LMNA (0.37) | LMNAALDH1A1KDM4ECYP3A4RECQL | |
| SCHEMBL9709985 | 0.60 | LMNA (0.34) | LMNAALDH1A1KDM4EPOLBKMT2A | |
| Bromide SCHEMBL8941015 | 0.59 | — | — | |
| SCHEMBL9825290 | 0.59 | KMT2A (0.43) | LMNACYP3A4POLBCYP2D6CYP2C19 | |
| SCHEMBL19962102 | 0.57 | CYP2D6 (0.66) | LMNAALDH1A1KDM4ECYP3A4RECQL | |
| SCHEMBL6792682 | 0.57 | TSHR (0.45) | LMNACYP3A4POLBCYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180463-B2 | Thiazole inner salt compounds, and preparation methods and uses thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2021-11-23 | — | — | US | disclosed |
| CN-107118175-B | The preparation method and purposes of salt compounds in thiazole | 中国人民解放军军事医学科学院毒物药物研究所 | 2019-08-20 | — | — | CN | disclosed |
| US-20190233383-A1 | THIAZOLE INNER SALT COMPOUNDS, AND PREPARATION METHODS AND USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2019-08-01 | — | — | US | disclosed |
| EP-3020711-B1 | THIAZOLE INNER SALT COMPOUNDS AND PREPARATION METHOD AND USE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2019-05-22 | — | — | EP | disclosed |
| CN-105377823-B | Thiazole inner salt compound, preparation method and application thereof | 中国人民解放军军事医学科学院毒物药物研究所 | 2017-12-01 | — | — | CN | disclosed |
| CN-107118175-A | The preparation method and purposes of salt compounds in thiazole | 中国人民解放军军事医学科学院毒物药物研究所 | 2017-09-01 | — | — | CN | disclosed |
| US-20160137619-A1 | Thiazole Inner Salt Compounds, and Preparation Methods and Uses Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2016-05-19 | — | — | US | disclosed |
| EP-3020711-A1 | THIAZOLE INNER SALT COMPOUNDS AND PREPARATION METHOD AND USE THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L. A. China (CN) | 2016-05-18 | — | — | EP | disclosed |
| CN-105377823-A | Thiazole inner salt compound, preparation method and application thereof | INST PHARMACOLOGY & TOXICOLOGY ACAD MILITARY MEDICAL SCIENCES PLA CHINA | 2016-03-02 | — | — | CN | disclosed |
| CN-104277011-A | Thiazolium inner salt compound and its use in treatment on protein aging-related diseases | INST PHARM & TOXICOLOGY AMMS | 2015-01-14 | — | — | CN | disclosed |
| EP-2341048-B1 | THIAZOLIUM SALT COMPOUND AND ITS USE FOR TREATING PROTEIN AGING ASSOCIATED DISEASES | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO LTD (CN) | 2013-03-06 | — | — | EP | disclosed |
| US-8338616-B2 | Thiazoliums and their use for treating protein aging associated diseases | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2012-12-25 | — | — | US | disclosed |
| US-20110178141-A1 | Thiazoliums and Their Use for Treating Protein Aging Associated Diseases | BEIJING MOLECULE SCIENCE AND TECHNOLOGY CO., LTD. (CN) | 2011-07-21 | — | — | US | disclosed |
| EP-2341048-A1 | THIAZOLIUM SALT COMPOUND AND THE USE OF TREATING THE PROTEIN AGING DISEASE | Beijing Molecule Science and Technology Co., Ltd. (CN) | 2011-07-06 | — | — | EP | disclosed |
| CN-101684106-A | Thiazole onium salt compound and application for treating diseases relative to protein aging thereof | BEIJING MOLYKOTE TECHNOLOGY CO | 2010-03-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178141-A1 | Thiazoliums and Their Use for Treating Protein Aging Associated Diseases | TTR, MTPN, TFEB | LMNA 1462/4885ALDH1A1 2281/4885KDM4E 3126/4885 |
| US-20190233383-A1 | THIAZOLE INNER SALT COMPOUNDS, AND PREPARATION METHODS AND USES THEREOF | PTMS, FURIN, F12 | LMNA 2251/4885ALDH1A1 466/4885KDM4E 2885/4885 |
| US-11180463-B2 | Thiazole inner salt compounds, and preparation methods and uses thereof | PTMS, FURIN, F12 | LMNA 2251/4885ALDH1A1 466/4885KDM4E 2885/4885 |
| US-20160137619-A1 | Thiazole Inner Salt Compounds, and Preparation Methods and Uses Thereof | PTMS, FURIN, F12 | LMNA 2251/4885ALDH1A1 466/4885KDM4E 2885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.