Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 1/20 | 0.43 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MGMT | P16455 | 3/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL27780172 | 1.00 | PNP (0.43) | PNPDPP4GDAPDPK1CDK2 | |
| SCHEMBL27975255 | 0.92 | PNP (0.49) | PNPDPP4GDAPDPK1CDK2 | |
| Phosphoric Acid SCHEMBL27758697 | 0.84 | PNP (0.44) | PNPDPP4GDAPDPK1CDK2 | |
| Phosphoric Acid SCHEMBL27758691 | 0.84 | PNP (0.44) | PNPDPP4GDAPDPK1CDK2 | |
| SCHEMBL29350757 | 0.81 | PNP (0.44) | PNPDPP4GDAPDPK1CDK2 | |
| SCHEMBL16767176 | 0.77 | PNP (0.41) | PNPDPP4GDAPDPK1CDK2 | |
| SCHEMBL2983851 | 0.76 | PNP (0.49) | PNPDPP4GDAPDPK1CDK2 | |
| Water SCHEMBL9697811 | 0.75 | PNP (0.47) | PNPDPP4GDAPDPK1CDK2 | |
| SCHEMBL41788 | 0.74 | PNP (0.50) | PNPDPP4GDAPDPK1CDK2 | |
| SCHEMBL8886040 | 0.73 | PNP (0.49) | PNPDPP4GDAPDPK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101495504-A | Materials and methods for the generation of fully 2'-modified nucleic acid transcripts | ARCHEMIX CORP (US) | 2009-07-29 | — | — | CN | claimed |
| CN-101495504-A | Materials and methods for the generation of fully 2'-modified nucleic acid transcripts | ARCHEMIX CORP (US) | 2009-07-29 | — | — | CN | disclosed |