Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 3/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27782001 | 0.96 | P2RX7 (0.32) | GRM2CNR1CNR2TDP1L3MBTL1 | |
| SCHEMBL27760474 | 0.85 | GRM2 (0.35) | GRM2SCN9AARCNR1CNR2 | |
| SCHEMBL27760475 | 0.85 | SCN9A (0.34) | SCN9A | |
| SCHEMBL27782005 | 0.73 | L3MBTL1 (0.33) | TDP1L3MBTL1P2RX7 | |
| SCHEMBL27781997 | 0.69 | L3MBTL1 (0.33) | TDP1L3MBTL1 | |
| SCHEMBL75173 | 0.67 | CNR1 (0.38) | GRM2SCN9ACNR1CNR2TDP1 | |
| SCHEMBL76310 | 0.63 | SLC16A1 (0.36) | GRM2CNR1CNR2TDP1L3MBTL1 | |
| SCHEMBL27760467 | 0.62 | L3MBTL1 (0.35) | TDP1L3MBTL1P2RX7 | |
| SCHEMBL76230 | 0.62 | L3MBTL1 (0.37) | GRM2CNR1CNR2TDP1L3MBTL1 | |
| SCHEMBL320896 | 0.59 | IDO1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101553474-A | Imidazolidinone and imidazolidinone derivatives as 11 b-HSD 1 inhibitors for diabetes | HOFFMANN LA ROCHE (CH) | 2009-10-07 | — | — | CN | claimed |
| CN-101553474-A | Imidazolidinone and imidazolidinone derivatives as 11 b-HSD 1 inhibitors for diabetes | HOFFMANN LA ROCHE (CH) | 2009-10-07 | — | — | CN | disclosed |