Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | PDE5A | O76074 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PDE1A | P54750 | 1/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | KDM4B | O94953 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91391 | 0.85 | KDM4E (0.69) | SMN1; SMN2NPC1RAB9AKDM4EPDE5A | |
| SCHEMBL4865927 | 0.81 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1RAB9AKMT2AMAPT | |
| SCHEMBL2664522 | 0.80 | KDM4E (0.66) | SMN1; SMN2NPC1RAB9AKDM4EPDE5A | |
| SCHEMBL27599948 | 0.80 | KDM4E (0.78) | SMN1; SMN2NPC1RAB9AKDM4EPDE5A | |
| SCHEMBL2227204 | 0.80 | KDM4E (0.69) | SMN1; SMN2NPC1RAB9AKDM4EPDE5A | |
| SCHEMBL2664517 | 0.80 | KDM4E (0.69) | SMN1; SMN2NPC1RAB9AKDM4EPDE5A | |
| SCHEMBL27782868 | 0.77 | AOC3 (0.74) | SMN1; SMN2NPC1RAB9AKDM4EPDE5A | |
| SCHEMBL5717620 | 0.77 | KDM4E (0.74) | SMN1; SMN2NPC1RAB9AKDM4EPDE5A | |
| SCHEMBL4782084 | 0.77 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL3594194 | 0.77 | RAB9A (1.00) | SMN1; SMN2NPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101747327-A | Aromatic amide thiazole derivative, preparation method and application thereof | UNIV BEIJING | 2010-06-23 | — | — | CN | claimed |
| CN-101747327-B | Aromatic amide thiazole derivative, preparation method and application thereof | UNIV BEIJING | 2013-03-27 | — | — | CN | disclosed |
| CN-101747327-A | Aromatic amide thiazole derivative, preparation method and application thereof | UNIV BEIJING | 2010-06-23 | — | — | CN | disclosed |