Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | PDE5A | O76074 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | PDE1A | P54750 | 1/20 | 0.57 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.57 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.57 |
| ▸ | KDM4A | O75164 | 1/20 | 0.57 |
| ▸ | KDM4B | O94953 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.57 |
| ▸ | SCD | O00767 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717620 | 0.86 | KDM4E (0.74) | KDM4EPDE5ANPC1RAB9AAOC3 | |
| SCHEMBL2664517 | 0.85 | KDM4E (0.69) | KDM4EPDE5ANPC1RAB9AAOC3 | |
| SCHEMBL27599948 | 0.85 | KDM4E (0.78) | KDM4EPDE5ANPC1RAB9AAOC3 | |
| SCHEMBL91391 | 0.85 | KDM4E (0.69) | KDM4EPDE5ANPC1RAB9AAOC3 | |
| SCHEMBL27782868 | 0.83 | AOC3 (0.74) | KDM4EPDE5ANPC1RAB9AAOC3 | |
| SCHEMBL2664522 | 0.83 | KDM4E (0.66) | KDM4EPDE5ANPC1RAB9AAOC3 | |
| SCHEMBL6919140 | 0.82 | KDM4E (0.64) | KDM4EPDE5ANPC1RAB9AAOC3 | |
| SCHEMBL17674539 | 0.81 | SMN1; SMN2 (0.50) | KDM4EPDE5ANPC1RAB9AAOC3 | |
| SCHEMBL25720785 | 0.81 | PDE5A (0.79) | KDM4EPDE5ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4874993 | 0.80 | AOC3 (0.74) | KDM4EPDE5ANPC1RAB9AAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526090-B1 | NEW ANTI-MALARIAL AGENTS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2015-08-19 | — | — | EP | disclosed |
| US-9024033-B2 | Anti-malarial agents | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2015-05-05 | — | — | US | disclosed |
| US-20120295905-A1 | NEW ANTI-MALARIAL AGENTS | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2012-11-22 | — | — | US | disclosed |
| WO-2011086531-A2 | NEW ANTI-MALARIAL AGENTS | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2011-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295905-A1 | NEW ANTI-MALARIAL AGENTS | QDPR, DHFR, ITPA | KDM4E 444/4885PDE5A 524/4885NPC1 3217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.