Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2585360 | 0.77 | DHODH (0.46) | POLBMAPTSMN1; SMN2NR4A3NR4A1 | |
| SCHEMBL29520867 | 0.77 | DHODH (0.46) | POLBMAPTSMN1; SMN2NR4A3NR4A1 | |
| Hydrochloric Acid SCHEMBL6809142 | 0.75 | DHODH (0.44) | POLBMAPTSMN1; SMN2NR4A3NR4A1 | |
| SCHEMBL18937274 | 0.73 | KDM4E (0.46) | POLBMAPTSMN1; SMN2NR4A3NR4A1 | |
| SCHEMBL6013338 | 0.72 | KMO (0.43) | POLBMAPTSMN1; SMN2NR4A3NR4A1 | |
| SCHEMBL28448801 | 0.71 | RECQL (0.54) | POLBNR4A3NR4A1NR4A2HSD17B10 | |
| Indazole Carboxamide SCHEMBL42505 | 0.70 | SLC22A12 (0.53) | POLBSMN1; SMN2HSD17B10L3MBTL1CHEK1 | |
| SCHEMBL28321271 | 0.70 | PARP1 (0.46) | SMN1; SMN2RIPK2PARP1PLK4CHEK1 | |
| SCHEMBL29520631 | 0.69 | PARP1 (0.49) | SMN1; SMN2RIPK2PARP1PLK4CHEK1 | |
| SCHEMBL534347 | 0.68 | RIPK2 (0.42) | MAPTSMN1; SMN2RIPK2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101932572-A | Pharmaceutically acceptable salts of 2- {4- [ (3S) -piperidin-3-yl ] phenyl } -2H-indazole-7-carboxamide | MERCK & CO INC | 2010-12-29 | — | — | CN | disclosed |
| CN-101541757-A | Pyrazolines as Mineralocorticoid Receptor Antagonists | PFIZER PROD INC (US) | 2009-09-23 | — | — | CN | disclosed |