Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2774415 | 0.98 | ALOX5 (0.57) | ALOX5MAPTL3MBTL1TDP1BRD4 | |
| Thiophene SCHEMBL27871601 | 0.89 | ALOX5 (0.49) | ALOX5MAPTL3MBTL1TDP1BRD4 | |
| SCHEMBL29177922 | 0.87 | ALOX5 (0.50) | ALOX5MAPTL3MBTL1TDP1BRD4 | |
| SCHEMBL9093133 | 0.87 | ALOX5 (0.50) | ALOX5MAPTL3MBTL1TDP1BRD4 | |
| SCHEMBL30208696 | 0.85 | ALOX5 (0.48) | ALOX5MAPTL3MBTL1TDP1MEN1 | |
| SCHEMBL21523872 | 0.85 | ALOX5 (0.48) | ALOX5MAPTL3MBTL1TDP1MEN1 | |
| SCHEMBL22581204 | 0.85 | ALOX5 (0.48) | ALOX5MAPTL3MBTL1TDP1MEN1 | |
| SCHEMBL4074613 | 0.85 | ALOX5 (0.48) | ALOX5MAPTL3MBTL1TDP1MEN1 | |
| SCHEMBL18834556 | 0.84 | ALOX5 (0.47) | ALOX5MAPTL3MBTL1TDP1BRD4 | |
| SCHEMBL3810808 | 0.84 | ALOX5 (0.47) | ALOX5MAPTL3MBTL1TDP1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7794858-B2 | Phenylphenoxazine or phenylphenothiazine- based compound and organic electroluminescent device using the same | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2010-09-14 | — | — | US | claimed |
| US-20090026928-A1 | PHENYLPHENOXAZINE OR PHENYLPHENOTHIAZINE- BASED COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2009-01-29 | — | — | US | claimed |
| US-7794858-B2 | Phenylphenoxazine or phenylphenothiazine- based compound and organic electroluminescent device using the same | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2010-09-14 | — | — | US | disclosed |
| US-20090026928-A1 | PHENYLPHENOXAZINE OR PHENYLPHENOTHIAZINE- BASED COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME | SAMSUNG ELECTRONICS CO., LTD. (KR) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090026928-A1 | PHENYLPHENOXAZINE OR PHENYLPHENOTHIAZINE- BASED COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME | TYR, MITF, PPOX | ALOX5 400/4885MAPT 353/4885L3MBTL1 2826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.