SCHEMBL2778468

SCHEMBL2778468

NC(=O)C(=O)NCC(F)(F)F

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.35
LOXL2 Q9Y4K0 1/20 0.34
LMNA P02545 2/20 0.33
HTT P42858 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
GAA P10253 1/20 0.32
KDM4E B2RXH2 1/20 0.31
MAPK14 Q16539 1/20 0.31
TGFBR1 P36897 1/20 0.31
POLB P06746 2/20 0.31
ALDH1A1 P00352 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL308777 0.79
SCHEMBL8681487 0.77 GAA (0.32) GAAKDM4ETGFBR1
SCHEMBL22702476 0.77 KDM5B (0.36) SMN1; SMN2LOXL2LMNAHTTL3MBTL1
Hydrochloric Acid SCHEMBL28213551 0.77 LMNA (0.36) SMN1; SMN2LOXL2LMNAHTTL3MBTL1
SCHEMBL13504795 0.76 LOXL2 (0.36) SMN1; SMN2LOXL2LMNAHTTL3MBTL1
SCHEMBL8069709 0.75 KDM4E (0.35) GAAKDM4ETGFBR1
SCHEMBL4560265 0.75 SMN1; SMN2 (0.35) SMN1; SMN2LOXL2LMNAHTTL3MBTL1
SCHEMBL9615512 0.75 SMN1; SMN2 (0.42) SMN1; SMN2LMNAGAAKDM4ETGFBR1
SCHEMBL22689217 0.73 SMN1; SMN2 (0.34) SMN1; SMN2LOXL2LMNAHTTL3MBTL1
SCHEMBL3917161 0.73 LMNA (0.37) SMN1; SMN2LOXL2LMNAHTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 230 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3646731-A1 PESTICIDAL MIXTURES COMPRISING A PYRAZOLE COMPOUND BASF SE (DE) 2020-05-06 EP claimed
EP-3300602-B1 PESTICIDAL MIXTURES COMPRISING A PYRAZOLE COMPOUND BASF SE (DE) 2020-03-25 EP claimed
EP-3300602-A1 PESTICIDAL MIXTURES COMPRISING A PYRAZOLE COMPOUND BASF SE (DE) 2018-04-04 EP claimed
EP-2379537-B9 Isoxazoline derivatives and their use as pesticide NOVARTIS AG (CH) 2017-07-12 EP claimed
US-20160219872-A1 Foamable Pesticide Compositions And Methods Of Application BASF CORPORATION 2016-08-04 US claimed
US-9339030-B2 Foamable pesticide compositions and methods of application BASF CORPORATION (US) 2016-05-17 US claimed
US-9044389-B2 Isoxazoline derivatives as pesticides NOVARTIS TIERGESUNDHEIT AG (CH) 2015-06-02 US claimed
EP-2864320-A1 PYRAZOLE COMPOUND AND PESTICIDAL MIXTURES COMPRISING A PYRAZOLE COMPOUND BASF SE (DE) 2015-04-29 EP claimed
US-20150105258-A1 Methods For Controlling Pests BASF CORPORATION (US) 2015-04-16 US claimed
US-8980294-B2 Methods for controlling pests BASF CORPORATION (US) 2015-03-17 US claimed
WO-2012084670-A1 PESTICIDAL ACTIVE MIXTURES COMPRISING PYRAZOLE COMPOUNDS BASF SE (DE) 2012-06-28 WO claimed
US-20120149570-A1 Foamable Pesticide Compositions And Methods Of Application BASF CORPORATION (US) 2012-06-14 US claimed
US-20100322892-A1 PESTICIDE COMPOSITIONS AND APPLICATORS BASF CORPORATION (US) 2010-12-23 US claimed
US-20100323897-A1 FOAMABLE PESTICIDE COMPOSITIONS BASF CORPORATION (US) 2010-12-23 US claimed
US-20100322990-A1 METHODS FOR CONTROLLING PESTS BASF CORPORATION (US) 2010-12-23 US claimed
WO-2010129345-A2 FOAMABLE PESTICIDE COMPOSITIONS BASF CORPORATION (US) 2010-11-11 WO claimed
WO-2010127019-A1 PESTICIDE COMPOSITIONS AND APPLICATORS BASF CORPORATION (US) 2010-11-04 WO claimed
WO-2010070068-A2 ORGANIC COMPOUNDS NOVARTIS AG (CH) 2010-06-24 WO claimed
EP-1377543-A1 OXALIC ACID DERIVATIVES MERCK PATENT GmbH (DE) 2004-01-07 EP claimed
WO-2002083630-A1 OXALIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2002-10-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120149570-A1 Foamable Pesticide Compositions And Methods Of Application DDT, PLD1, ACHE SMN1; SMN2 1819/4885LOXL2 778/4885LMNA 409/4885
US-20100323897-A1 FOAMABLE PESTICIDE COMPOSITIONS DDT, PON1, ACHE SMN1; SMN2 2264/4885LOXL2 1300/4885LMNA 2319/4885
US-20100322990-A1 METHODS FOR CONTROLLING PESTS DDT, ACHE, PON1 SMN1; SMN2 1236/4885LOXL2 997/4885LMNA 1606/4885
US-20100322892-A1 PESTICIDE COMPOSITIONS AND APPLICATORS DDT, ACHE, CHRM2 SMN1; SMN2 3058/4885LOXL2 3630/4885LMNA 3123/4885
US-20150105258-A1 Methods For Controlling Pests DDT, ACHE, PON1 SMN1; SMN2 1236/4885LOXL2 997/4885LMNA 1606/4885
US-20160219872-A1 Foamable Pesticide Compositions And Methods Of Application DDT, PLD1, ACHE SMN1; SMN2 1819/4885LOXL2 778/4885LMNA 409/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.