Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 5/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | ITK | Q08881 | 2/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.47 |
| ▸ | CDK2 | P24941 | 3/20 | 0.47 |
| ▸ | CDK7 | P50613 | 3/20 | 0.47 |
| ▸ | CCNH | P51946 | 3/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.47 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27739021 | 0.90 | CDK12 (0.53) | CCNKCDK12GAAEGFRITK | |
| SCHEMBL13605582 | 0.87 | SIRT5 (0.59) | CCNKCDK12GAAGFERCCNA2 | |
| SCHEMBL13605575 | 0.87 | GRM3 (0.52) | CCNKCDK12GAAGFERSIRT5 | |
| SCHEMBL1734300 | 0.85 | ALDH1A1 (0.49) | CCNKCDK12GAASIRT5NTRK1 | |
| SCHEMBL13605608 | 0.85 | RAB9A (0.54) | CDK2NTRK1 | |
| SCHEMBL13605580 | 0.84 | GRM5 (0.54) | CDK2NTRK1 | |
| SCHEMBL13605609 | 0.84 | LRRK2 (0.48) | CCNKCDK12 | |
| SCHEMBL13605579 | 0.82 | KMT2A (0.52) | NTRK1 | |
| SCHEMBL13659590 | 0.80 | MEN1 (0.51) | CCNKCDK12SIRT5NTRK1 | |
| SCHEMBL1734419 | 0.80 | L3MBTL3 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101272685-A | Diarylamine-containing compounds and compositions, and their use as modulators of C-KIT receptors | IRM LLC (BM) | 2008-09-24 | — | — | CN | claimed |
| CN-101272685-A | Diarylamine-containing compounds and compositions, and their use as modulators of C-KIT receptors | IRM LLC (BM) | 2008-09-24 | — | — | CN | disclosed |