Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | BMI1 | P35226 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27785768 | 0.90 | EGFR (0.47) | EGFRBTKGSK3AGSK3BABL1 | |
| SCHEMBL3651887 | 0.83 | PTK2 (0.47) | KMT2ASYKMCHR1PTK2POLB | |
| SCHEMBL3651931 | 0.82 | GRM5 (0.40) | EGFRBTKGRM5GSK3AGSK3B | |
| SCHEMBL3644492 | 0.82 | LTA4H (0.49) | EGFRSYKMCHR1PTK2 | |
| SCHEMBL3647442 | 0.81 | LTA4H (0.42) | EGFRBTKGRM5SYKPTK2 | |
| SCHEMBL27807596 | 0.80 | GRM5 (0.39) | EGFRBTKGRM5ABL1SYK | |
| SCHEMBL12442985 | 0.79 | L3MBTL1 (0.42) | EGFRBTKGRM5PTK2POLB | |
| SCHEMBL12443126 | 0.78 | EGFR (0.39) | EGFRBTKGRM5GSK3AGSK3B | |
| SCHEMBL3652561 | 0.77 | EGFR (0.40) | EGFRBTKGSK3AGSK3BALDH1A1 | |
| SCHEMBL3650207 | 0.77 | GPR6 (0.41) | EGFRBTKMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | claimed |
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | disclosed |