Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3651887 | 0.86 | PTK2 (0.47) | PTK2POLBS1PR5SYK | |
| SCHEMBL3644492 | 0.86 | LTA4H (0.49) | EGFRPTK2S1PR5SYKHDAC1 | |
| SCHEMBL3647442 | 0.85 | LTA4H (0.42) | GRM5EGFRBTKPTK2POLB | |
| SCHEMBL3650935 | 0.84 | ACHE (0.40) | ABL1EGFRBTKPTK2POLB | |
| SCHEMBL12442985 | 0.83 | L3MBTL1 (0.42) | GRM5EGFRBTKPTK2POLB | |
| SCHEMBL3654033 | 0.82 | EGFR (0.39) | GRM5ABL1EGFRBTKMELK | |
| SCHEMBL3651931 | 0.82 | GRM5 (0.40) | GRM5EGFRBTKPTK2CSNK2A1 | |
| SCHEMBL12443126 | 0.82 | EGFR (0.39) | GRM5EGFRBTKPOLBCNR2 | |
| SCHEMBL3652561 | 0.81 | EGFR (0.40) | ABL1EGFRBTKPTK2POLB | |
| SCHEMBL3650207 | 0.81 | GPR6 (0.41) | EGFRBTKPTK2POLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | claimed |
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | disclosed |