Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.30 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1772263 | 0.78 | — | — | |
| SCHEMBL9036061 | 0.77 | TSHR (0.46) | USP2TSHRKMT2AMEN1 | |
| SCHEMBL28580193 | 0.76 | EPHX1 (0.55) | DPP7 | |
| SCHEMBL8212374 | 0.76 | GNAI3 (0.46) | USP2TSHRKMT2AALDH1A1DPP7 | |
| SCHEMBL28559240 | 0.76 | EPHX1 (0.55) | DPP7 | |
| SCHEMBL27340657 | 0.75 | TSHR (0.41) | USP2TSHRKMT2AALDH1A1MEN1 | |
| SCHEMBL11202268 | 0.73 | ALDH1A1 (0.42) | USP2TSHRKMT2AALDH1A1MAPT | |
| SCHEMBL843281 | 0.73 | — | — | |
| SCHEMBL8083315 | 0.72 | CYP2C19 (0.48) | USP2TSHRKMT2AALDH1A1MEN1 | |
| SCHEMBL6272869 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101600698-B | Quinazolinone and isoquinolinone acetamide derivatives | ORGANON NV | 2012-01-11 | — | — | CN | disclosed |
| CN-101600698-A | Quinazolinone and isoquinolinone acetamide derivatives | ORGANON NV (NL) | 2009-12-09 | — | — | CN | disclosed |