Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27789001 | 0.89 | MEN1 (0.53) | TSHRKMT2AMEN1CYP3A4PTGS1 | |
| SCHEMBL3422296 | 0.83 | KMT2A (0.48) | TSHRKMT2AMEN1CYP3A4PTGS1 | |
| SCHEMBL16284311 | 0.81 | CYP3A4 (0.63) | TSHRKMT2AMEN1CYP3A4PTGS1 | |
| SCHEMBL29924838 | 0.81 | GSK3B (0.43) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL28080415 | 0.79 | MEN1 (0.45) | TSHRKMT2AMEN1CYP3A4PTGS1 | |
| SCHEMBL27841431 | 0.79 | MEN1 (0.45) | TSHRKMT2AMEN1CYP3A4PTGS1 | |
| SCHEMBL11217214 | 0.78 | KMT2A (0.48) | TSHRKMT2AMEN1CYP3A4PTGS1 | |
| SCHEMBL9720561 | 0.77 | CYP3A4 (0.47) | TSHRKMT2AMEN1CYP3A4PTGS1 | |
| SCHEMBL28091408 | 0.76 | KMT2A (0.49) | KMT2AMEN1CYP3A4PTGS1DRD3 | |
| SCHEMBL28174203 | 0.76 | TSHR (0.47) | TSHRKMT2AMEN1CYP3A4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101809005-B | Fused bicyclic compound | MITSUBISHI TANABE PHARMA CORP | 2013-05-01 | — | — | CN | disclosed |
| CN-101809005-A | Fused bicyclic compound | MITSUBISHI TANABE PHARMA CORP | 2010-08-18 | — | — | CN | disclosed |