SCHEMBL3422296

SCHEMBL3422296

CCC(=O)c1c(F)cc(F)cc1F

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.48
MEN1 O00255 2/20 0.48
CYP3A4 P08684 1/20 0.48
PTGS1 P23219 1/20 0.48
DRD3 P35462 1/20 0.48
GAA P10253 1/20 0.41
CES2 O00748 4/20 0.40
CES1 P23141 4/20 0.40
RIPK1 Q13546 4/20 0.39
MAPT P10636 2/20 0.38
ERN1 O75460 1/20 0.38
TSHR P16473 2/20 0.37
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37
HSP90AB1 P08238 1/20 0.35
PLK1 P53350 1/20 0.35
PLK3 Q9H4B4 1/20 0.35
HTR7 P34969 1/20 0.34
PKM P14618 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16284311 0.84 CYP3A4 (0.63) KMT2AMEN1CYP3A4PTGS1DRD3
SCHEMBL28080415 0.83 MEN1 (0.45) KMT2AMEN1CYP3A4PTGS1DRD3
SCHEMBL27788907 0.83 TSHR (0.46) KMT2AMEN1CYP3A4PTGS1DRD3
SCHEMBL27841431 0.83 MEN1 (0.45) KMT2AMEN1CYP3A4PTGS1DRD3
SCHEMBL28312119 0.80 MEN1 (0.69) KMT2AMEN1CYP3A4PTGS1DRD3
SCHEMBL28091408 0.79 KMT2A (0.49) KMT2AMEN1CYP3A4PTGS1DRD3
SCHEMBL23516375 0.78 PLA2G2A (0.54) KMT2AMEN1MAPTALDH1A1HTR7
SCHEMBL2381912 0.77 CES2 (0.40) KMT2AGAACES2CES1MAPT
SCHEMBL6194822 0.77 PTPN1 (0.48) KMT2AGAACES2CES1ERN1
SCHEMBL1162543 0.77 CES2 (0.56) KMT2AMEN1CYP3A4PTGS1DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3611164-B1 PYRIDONE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE HAVING THIS AS ACTIVE COMPONENT MITSUI CHEMICALS CROP & LIFE SOLUTIONS INC (JP) 2024-08-28 EP disclosed
CN-110234627-B Pyridone compound and agricultural/horticultural bactericide containing pyridone compound as active ingredient 三井化学植保株式会社 2023-09-01 CN disclosed
EP-3611165-B1 PYRIDONE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE HAVING THIS AS ACTIVE COMPONENT MITSUI CHEMICALS CROP & LIFE SOLUTIONS INC (JP) 2023-08-16 EP disclosed
EP-3611165-B1 PYRIDONE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE HAVING THIS AS ACTIVE COMPONENT MITSUI CHEMICALS CROP & LIFE SOLUTIONS INC (JP) 2023-08-16 EP disclosed
US-11178870-B2 Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients MITSUI CHEMICALS AGRO, INC. (JP) 2021-11-23 US disclosed
US-11178870-B2 Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients MITSUI CHEMICALS AGRO, INC. (JP) 2021-11-23 US disclosed
US-11147272-B2 Pyridone compounds and agricultural and horticultural fungicides comprising the same as active ingredients MITSUI CHEMICALS ARGRO, INC. (JP) 2021-10-19 US disclosed
US-11147272-B2 Pyridone compounds and agricultural and horticultural fungicides comprising the same as active ingredients MITSUI CHEMICALS ARGRO, INC. (JP) 2021-10-19 US disclosed
EP-3611165-A1 PYRIDONE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE HAVING THIS AS ACTIVE COMPONENT Mitsui Chemicals Agro, Inc. (JP) 2020-02-19 EP disclosed
EP-3611165-A1 PYRIDONE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL FUNGICIDE HAVING THIS AS ACTIVE COMPONENT Mitsui Chemicals Agro, Inc. (JP) 2020-02-19 EP disclosed
US-20200045963-A1 PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES COMPRISING THE SAME AS ACTIVE INGREDIENTS MITSUI CHEMICALS AGRO, INC. (JP) 2020-02-13 US disclosed
US-20200045968-A1 PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS MITSUI CHEMICALS AGRO, INC. (JP) 2020-02-13 US disclosed
US-20200045963-A1 PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES COMPRISING THE SAME AS ACTIVE INGREDIENTS MITSUI CHEMICALS AGRO, INC. (JP) 2020-02-13 US disclosed
US-20200045968-A1 PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS MITSUI CHEMICALS AGRO, INC. (JP) 2020-02-13 US disclosed
CN-110167348-A Parasitic pest expellent and its application method using pyridinone compounds as effective component 三井化学AGRO株式会社 2019-08-23 CN disclosed
CN-102271508-B Pyrido (4,3-b) indoles containing rigid moieties MEDIVATION TECHNOLOGIES INC 2015-04-29 CN disclosed
CN-102316732-B Azepino [4, 5-b] indoles and methods of use MEDIVATION TECHNOLOGIES INC 2015-04-01 CN disclosed
CN-102083835-A Bridged, bicyclic heterocyclic or spiro bicyclic heterocyclic derivatives of pyrazolo[1,5-A]pyrimidines, methods for preparation and uses thereof WYETH CORP 2011-06-01 CN disclosed
WO-2011032277-A1 QUINAZOLINONE DERIVATIVES AS VIRAL POLYMERASE INHIBITORS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-03-24 WO disclosed
US-20100160385-A1 FUNGICIDAL TRIPHENYL-SUBSTITUTED PYRIDONES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2010-06-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11178870-B2 Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients PNPO, CYP4X1, PDXK KMT2A 1335/4885MEN1 511/4885CYP3A4 19/4885
US-20200045963-A1 PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES COMPRISING THE SAME AS ACTIVE INGREDIENTS PNPO, PDXK, PLPBP KMT2A 2448/4885MEN1 161/4885CYP3A4 40/4885
US-20200045968-A1 PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS PNPO, CYP4X1, PDXK KMT2A 1335/4885MEN1 511/4885CYP3A4 19/4885
US-11147272-B2 Pyridone compounds and agricultural and horticultural fungicides comprising the same as active ingredients PNPO, PDXK, PLPBP KMT2A 2448/4885MEN1 161/4885CYP3A4 40/4885
US-20100160385-A1 FUNGICIDAL TRIPHENYL-SUBSTITUTED PYRIDONES PNPO, TH, CYP1A1 KMT2A 2898/4885MEN1 1455/4885CYP3A4 20/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.