Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4810104 | 0.92 | THRB (0.53) | THRBTSHRALDH1A1GLO1LMNA | |
| SCHEMBL1933622 | 0.89 | THRB (0.41) | THRBTSHRALDH1A1GLO1LMNA | |
| Methacrylic Acid SCHEMBL15456814 | 0.88 | THRB (0.53) | THRBTSHRALDH1A1GLO1LMNA | |
| SCHEMBL27832581 | 0.85 | ALDH1A1 (0.56) | THRBTSHRALDH1A1GLO1LMNA | |
| SCHEMBL28342228 | 0.85 | ALDH1A1 (0.56) | THRBTSHRALDH1A1GLO1LMNA | |
| Methylene Chloride SCHEMBL28244287 | 0.84 | THRB (0.57) | THRBTSHRALDH1A1GLO1LMNA | |
| Betaine SCHEMBL28482865 | 0.83 | TSHR (0.45) | THRBTSHRALDH1A1GLO1LMNA | |
| Acrylic Acid SCHEMBL28568730 | 0.82 | ALDH1A1 (0.44) | THRBTSHRALDH1A1GLO1MGAM | |
| Chloromethane SCHEMBL17453350 | 0.82 | THRB (0.59) | THRBTSHRALDH1A1GLO1LMNA | |
| Hydrogen Sulfide SCHEMBL11505632 | 0.82 | THRB (0.59) | THRBTSHRALDH1A1GLO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101583620-A | Ganaxolone compositions and methods of making and using the same | MARINUS PHARMACEUTICALS (US) | 2009-11-18 | — | — | CN | disclosed |