Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.67 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.67 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.67 |
| ▸ | GABRR1 | P24046 | 6/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | GABRP | O00591 | 3/20 | 0.36 |
| ▸ | GABRD | O14764 | 3/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.36 |
| ▸ | GABRE | P78334 | 3/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL8395156 | 0.93 | — | — | |
| Glycine SCHEMBL3384608 | 0.89 | — | — | |
| Glycine SCHEMBL246859 | 0.89 | GLRA1 (0.83) | GLRA1SLC6A9OR51E2GABRR1FFAR3 | |
| Glycine SCHEMBL27836964 | 0.86 | — | — | |
| Glycine SCHEMBL29220903 | 0.86 | — | — | |
| Glycine SCHEMBL474856 | 0.82 | — | — | |
| Glycine SCHEMBL28317820 | 0.82 | — | — | |
| Glycine SCHEMBL93765 | 0.82 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1FFAR3 | |
| Glycine SCHEMBL2116443 | 0.82 | — | — | |
| Glycine SCHEMBL3640989 | 0.82 | GLRA1 (1.00) | GLRA1SLC6A9OR51E2GABRR1FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101628878-A | N-hydroxymethylglycine phosphite, preparation thereof and application thereof | JIAN LI | 2010-01-20 | — | — | CN | disclosed |