Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | MTOR | P42345 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4619744 | 1.00 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL2778650 | 1.00 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL8249516 | 1.00 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL8251411 | 1.00 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL4620535 | 1.00 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL23911772 | 1.00 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL2778648 | 1.00 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5326481 | 0.99 | MEN1 (0.52) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL8276213 | 0.90 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL10041960 | 0.86 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010084459-A2 | IMPROVED PROCESS FOR PREPARING AN INTERMEDIATE OF SERTRALINE | PIRAMAL HEALTHCARE LIMITED (IN) | 2010-07-29 | — | — | WO | claimed |
| WO-2010076763-A2 | AN IMPROVED PROCESS FOR THE MANUFACTURE OF SERTRALINE | PIRAMAL HEALTHCARE LIMITED (IN) | 2010-07-08 | — | — | WO | claimed |
| EP-1885683-A2 | A HIGHLY STEREOSELECTIVE SYNTHESIS OF SERTRALINE | Hetero Drugs Limited (IN) | 2008-02-13 | — | — | EP | claimed |
| US-20070260090-A1 | Highly Steroselective Synthesis of Sertraline | HETERO DRUGS LIMITED (IN) | 2007-11-08 | — | — | US | claimed |
| WO-2007071421-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF SERTRALINE | SANDOZ AG (CH) | 2007-06-28 | — | — | WO | claimed |
| WO-2006129324-A2 | A HIGHLY STEREOSELECTIVE SYNTHESIS OF SERTRALINE | HETERO DRUGS LIMITED (IN) | 2006-12-07 | — | — | WO | claimed |
| WO-2004087732-A2 | PROCESS FOR THE PREPARATION OF (1S, 4S)-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPHTHYLAMINE | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2004-10-14 | — | — | WO | claimed |
| US-6723878-B2 | HYDROGENATING N-(4-(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)-NAPHTHALENYLIDENE)METHANAMINE IN THE PRESENCE OF A DEHALOGENATION INHIBITOR, E.G., TRIPHENYLPHOSPHITE OR TRIMETHYLPHOSPHITE AND A CATALYST | ORION CORPORATION FERMION (FI) | 2004-04-20 | — | — | US | claimed |
| EP-1401800-A1 | A NOVEL PROCESS FOR THE PREPARATION OF (IS-CIS) -4-(3, 4-DICHLOROPHENYL) -1, 2, 3, 4 - TETRAHYDRO-N-METHYL-1-NAPHTHALENAMINE | ORION CORPORATION FERMION (FI) | 2004-03-31 | — | — | EP | claimed |
| EP-1397342-A1 | PROCESS FOR PREPARING SERTRALINE INTERMEDIATES | ORION CORPORATION FERMION (FI) | 2004-03-17 | — | — | EP | claimed |
| WO-2002096860-A1 | PROCESS FOR PREPARING SERTRALINE INTERMEDIATES | ORION CORPORATION FERMION (FI) | 2002-12-05 | — | — | WO | claimed |
| US-6232500-B1 | REACTING 4-(3,4-DICHLOROPHENYL)-3,4-DIHYDRO-1(2H)-NAPTHALENONE WITH MONOMETHYLAMINE IN ALCOHOL SOLVENT HAVING SPECIFIED BOILING POINT, UNDER REACTION CONDITIONS, AND IN WHICH MONOMETHYLAMINE IS SOLUBLE | PFIZER INC | 2001-05-15 | — | — | US | claimed |
| EP-1073645-A2 | PROCESS FOR THE PREPARATION OF TETRALONE IMINES FOR THE PREPARATION OF ACTIVE PHARMACEUTICAL COMPOUNDS | Ciba SC Holding AG (CH) | 2001-02-07 | — | — | EP | claimed |
| EP-1059287-A1 | Process for preparing sertraline from chiral tetralone | Pfizer Products Inc. (US) | 2000-12-13 | — | — | EP | claimed |
| EP-1047666-A1 | NOVEL PROCESS FOR PREPARING A KETIMINE | Pfizer Products Inc. (US) | 2000-11-02 | — | — | EP | claimed |
| US-6054614-A | Process for the preparation of tetralone imines for the preparation of active pharmaceutical compounds | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2000-04-25 | — | — | US | claimed |
| WO-1999055686-A2 | PROCESS FOR THE PREPARATION OF TETRALONE IMINES FOR THE PREPARATION OF ACTIVE PHARMACEUTICAL COMPOUNDS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 1999-11-04 | — | — | WO | claimed |
| WO-1999036394-A1 | NOVEL PROCESS FOR PREPARING A KETIMINE | PFIZER PRODUCTS INC. (US) | 1999-07-22 | — | — | WO | claimed |
| EP-0341015-A2 | Improved process for preparing a ketimine | PFIZER INC. (US) | 1989-11-08 | — | — | EP | claimed |
| US-4855500-A | Process for preparing a ketimine | PFIZER INC. (US) | 1989-08-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070260090-A1 | Highly Steroselective Synthesis of Sertraline | HTR3A, TPH1, TPH2 | SLC6A2 60/4885SLC6A4 22/4885SLC6A3 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.