Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27776487 | 0.85 | MAPT (0.39) | MAPTKDM4EALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL27797299 | 0.84 | FADS1 (0.36) | MAPTKDM4ETDP1AGTR1AGTR2 | |
| SCHEMBL5129012 | 0.82 | MAPT (0.53) | MAPTKDM4ETDP1AGTR1AGTR2 | |
| SCHEMBL27776485 | 0.80 | MAPT (0.50) | MAPTKDM4ETDP1AGTR1AGTR2 | |
| SCHEMBL3953186 | 0.78 | MAPT (0.59) | MAPTKDM4ETDP1AGTR1AGTR2 | |
| SCHEMBL3955434 | 0.78 | MAPT (0.53) | MAPTKDM4ETDP1AGTR1AGTR2 | |
| SCHEMBL3959308 | 0.78 | MAPT (0.53) | MAPTKDM4ETDP1AGTR1AGTR2 | |
| SCHEMBL3961340 | 0.78 | MAPT (0.53) | MAPTKDM4ETDP1AGTR1AGTR2 | |
| SCHEMBL3959035 | 0.76 | MAPT (0.60) | MAPTKDM4ETDP1AGTR1AGTR2 | |
| SCHEMBL3959990 | 0.76 | MAPT (0.51) | MAPTKDM4ETDP1AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101636398-A | Pyridopyrimidinone compounds useful in treating sodium channel-mediated diseases or conditions | XENON PHARMACEUTICALS INC | 2010-01-27 | — | — | CN | claimed |
| CN-101636398-A | Pyridopyrimidinone compounds useful in treating sodium channel-mediated diseases or conditions | XENON PHARMACEUTICALS INC | 2010-01-27 | — | — | CN | disclosed |