Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8910156 | 0.93 | TRPA1 (0.81) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Acetic Acid SCHEMBL4221099 | 0.91 | TRPA1 (0.77) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL67369 | 0.88 | — | — | |
| SCHEMBL20563577 | 0.88 | TRPA1 (1.00) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Formaldehyde SCHEMBL27890391 | 0.86 | TRPA1 (0.85) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL7701981 | 0.85 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL1937642 | 0.85 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Pyrogallol SCHEMBL1937411 | 0.85 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL27454293 | 0.85 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Ammonia Solution, Strong SCHEMBL27883641 | 0.85 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101848726-A | The memory impairment that bryostatin, bryostatin analog and other related substances cause head trauma and the curative effect of brain injury | BRNI NEUROSCIENCES INST | 2010-09-29 | — | — | CN | disclosed |
| CN-101678080-A | Bryostatin, bryostatin analog and other related substances to ischemia/in the curative effect of wind-induced memory impairment and brain injury | BRNI NEUROSCIENCES INST | 2010-03-24 | — | — | CN | disclosed |