Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL4221099 | 0.93 | TRPA1 (0.77) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Oxalic Acid SCHEMBL27798141 | 0.93 | TRPA1 (0.77) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL20563577 | 0.90 | TRPA1 (1.00) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL67369 | 0.90 | — | — | |
| Formaldehyde SCHEMBL27890391 | 0.88 | TRPA1 (0.85) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL7701981 | 0.87 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL1937642 | 0.87 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Pyrogallol SCHEMBL1937411 | 0.87 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Hydrogen Sulfide SCHEMBL28290906 | 0.87 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Ammonia Solution, Strong SCHEMBL27883641 | 0.87 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8273700-A | — | — | None | — | — | JP | disclosed |
| CN-100342860-C | Antacid compositions | KOWA CO (JP) | 2007-10-17 | — | — | CN | disclosed |
| CN-1761474-A | Antacid compositions | KOWA CO (JP) | 2006-04-19 | — | — | CN | disclosed |
| US-5681669-A | ORGANIC SOLVENT CONTAINING AN AROMATIC CARBONATE AND DISSOLVED LITHIUM SALT | UBE INDUSTRIES, LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| JP-H08273700-A | ELECTROLYTE FOR LITHIUM SECONDARY BATTERY | UBE IND LTD | 1996-10-18 | — | — | JP | disclosed |