Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8910156 | 0.93 | TRPA1 (0.81) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Oxalic Acid SCHEMBL27798141 | 0.91 | TRPA1 (0.77) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Acetic Acid SCHEMBL28854366 | 0.88 | ALDH1A1 (0.74) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL67369 | 0.88 | — | — | |
| SCHEMBL20563577 | 0.88 | TRPA1 (1.00) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Formaldehyde SCHEMBL27890391 | 0.86 | TRPA1 (0.85) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL7701981 | 0.85 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL1937642 | 0.85 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| Pyrogallol SCHEMBL1937411 | 0.85 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL27454293 | 0.85 | TRPA1 (0.94) | TRPA1ALDH1A1HPGDHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190083575-A1 | THERAPEUTIC EFFECTS OF BRYOSTATINS, BRYOLOGS, AND OTHER RELATED SUBSTANCES ON HEAD TRAUMA-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY | COGNITIVE RES ENTERPRISES INC (US) | 2019-03-21 | — | — | US | disclosed |
| EP-3332797-A2 | THERAPEUTIC EFFECTS OF BRYOSTATINS, BRYOLOGS AND OTHER RELATED SUBSTANCES ON HEAD TRAUMA-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY | Blanchette Rockefeller Neurosciences Institute (US) | 2018-06-13 | — | — | EP | disclosed |
| US-9974832-B2 | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury | COGNITIVE RESEARCH ENTERPRISES, INC. (US) | 2018-05-22 | — | — | US | disclosed |
| EP-2959914-A1 | THERAPEUTIC EFFECTS OF BRYOLOGS ON HEAD TRAUMA-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY | Blanchette Rockefeller Neurosciences, Institute (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-2121001-B1 | THERAPEUTIC EFFECTS OF BRYOSTATINS ON ISCHEMIA/STROKE-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY | BRNI NEUROSCIENCES INST (US) | 2014-12-17 | — | — | EP | disclosed |
| EP-2737904-A2 | Therapeutic effects of bryostatins, bryologs, and other related substances on ischemia/stroke-induced memory impairment and brain injury | Blanchette Rockefeller Neurosciences Institute (US) | 2014-06-04 | — | — | EP | disclosed |
| US-20130165453-A1 | THERAPEUTIC EFFECTS OF BRYOSTATINS, BRYOLOGS, AND OTHER RELATED SUBSTANCES ON ISCHEMIA/STROKE-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY | BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE | 2013-06-27 | — | — | US | disclosed |
| EP-2121001-A2 | THERAPEUTIC EFFECTS OF BRYOSTATINS, BRYOLOGS, AND OTHER RELATED SUBSTANCES ON ISCHEMIA/STROKE-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY | Blanchette Rockefeller Neurosciences Institute (US) | 2009-11-25 | — | — | EP | disclosed |
| US-20090036514-A1 | Therapeutic effects of Bryostatins, Bryologs, and other related substances on Ischemia/stroke-induced memory impairment and brain injury | WEST VIRGINIA UNIVERSITY | 2009-02-05 | — | — | US | disclosed |
| WO-2008143880-A2 | THERAPEUTIC EFFECTS OF BRYOSTATINS, BRYOLOGS, AND OTHER RELATED SUBSTANCES ON HEAD TRAUMA-INDUCED MEMORY IMPAIRMENT AND TRAUMATIC BRAIN INJURY | BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE (US) | 2008-11-27 | — | — | WO | disclosed |
| US-20080207742-A1 | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury | COGNITIVE RESEARCH ENTERPRISES, INC. | 2008-08-28 | — | — | US | disclosed |
| WO-2008100450-A2 | THERAPEUTIC EFFECTS OF BRYOSTATINS, BRYOLOGS, AND OTHER RELATED SUBSTANCES ON ISCHEMIA/STROKE-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY | BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE (US) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165453-A1 | THERAPEUTIC EFFECTS OF BRYOSTATINS, BRYOLOGS, AND OTHER RELATED SUBSTANCES ON ISCHEMIA/STROKE-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY | BDNF, NGF, NTRK2 | TRPA1 2856/4885ALDH1A1 3253/4885HPGD 2721/4885 |
| US-20080207742-A1 | Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury | BDNF, NGF, NTRK2 | TRPA1 2723/4885ALDH1A1 3147/4885HPGD 2012/4885 |
| US-20090036514-A1 | Therapeutic effects of Bryostatins, Bryologs, and other related substances on Ischemia/stroke-induced memory impairment and brain injury | BDNF, NGF, NTRK2 | TRPA1 2856/4885ALDH1A1 3253/4885HPGD 2721/4885 |
| US-20190083575-A1 | THERAPEUTIC EFFECTS OF BRYOSTATINS, BRYOLOGS, AND OTHER RELATED SUBSTANCES ON HEAD TRAUMA-INDUCED MEMORY IMPAIRMENT AND BRAIN INJURY | BDNF, NGF, NTRK2 | TRPA1 2723/4885ALDH1A1 3147/4885HPGD 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.