Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2782921 | 0.81 | SLC6A2 (0.43) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| SCHEMBL5511404 | 0.79 | SLC6A2 (0.52) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| SCHEMBL15485782 | 0.77 | ALDH1A1 (0.39) | SLC6A4ALDH1A1CYP3A4HSD17B10TSHR | |
| SCHEMBL20928861 | 0.75 | CYP3A4 (0.40) | SLC6A4ALDH1A1CYP3A4HSD17B10TSHR | |
| SCHEMBL12303991 | 0.75 | TRPA1 (0.40) | SLC6A4SLC6A2ALDH1A1CYP3A4HSD17B10 | |
| SCHEMBL564275 | 0.74 | SLC6A2 (0.52) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| SCHEMBL25596207 | 0.74 | ESR1 (0.59) | SLC6A4SLC6A2HTR2AHRH1HTR2B | |
| SCHEMBL2780716 | 0.74 | HPGD (0.39) | ALDH1A1CYP3A4TSHRTAS1R3TAS1R1 | |
| SCHEMBL841432 | 0.73 | ALDH1A1 (0.40) | SLC6A4SLC6A2SLC6A3ALDH1A1CYP3A4 | |
| SCHEMBL12338829 | 0.73 | SLC6A4 (0.39) | SLC6A4SLC6A2ALDH1A1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010103429-A1 | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists | PFIZER INC. (US) | 2010-09-16 | — | — | WO | disclosed |
| WO-2010103429-A1 | 1,1-(Dimethyl-Ethylamino)-2-Hydroxy-Propoxy]-Ethyl}-3-Methyl-Biphenyl-4- Carboxylic Acid Derivatives As Calcium Receptor Antagonists | PFIZER INC. (US) | 2010-09-16 | — | — | WO | disclosed |