Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 9/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27678077 | 0.91 | FABP4 (0.38) | FABP4HTR6HTR2CHTR2AMAPT | |
| SCHEMBL27879774 | 0.86 | HTR6 (0.36) | FABP4HTR6SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL28750987 | 0.83 | HTT (0.46) | FABP4HTR6MAPTHTTNPSR1 | |
| SCHEMBL28799515 | 0.80 | HTR6 (0.35) | HTR6HTR2CHTR2ASLC1A3SLC1A2 | |
| SCHEMBL28946823 | 0.79 | HTR6 (0.53) | HTR6HTR2C | |
| SCHEMBL27799498 | 0.78 | MEN1 (0.30) | MEN1KMT2A | |
| SCHEMBL27773813 | 0.74 | RXFP1 (0.34) | HTR6MAPTLMNAKMT2A | |
| SCHEMBL1892821 | 0.74 | HTR6 (0.54) | FABP4HTR6SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL27634824 | 0.73 | PPARG (0.43) | FABP4RAPGEF4TDP1 | |
| SCHEMBL27677914 | 0.73 | HTR6 (0.42) | HTR6MAPTHTTNPSR1RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101939324-A | Pyrrolopyrazine kinase inhibitors | HOFFMANN LA ROCHE | 2011-01-05 | — | — | CN | disclosed |